Cardiology Research and Practice / 2012 / Article / Tab 3

Review Article

The Diabetic Heart: Too Sweet for Its Own Good?

Table 3

Studies indicating no difference in the sensitivity of the diabetic heart to ischemic injury compared to normoglycemic controls.

StudyModelIschemic ProtocolDuration/onset of diabetesSubstratesModel of diabetesEnd points

Hadour et al. (1998) [48]Rabbit, 10% glucose infusion to 300 mg/dL blood glucoseIn vivo nonrecovery, 30 min regional ischemia/3 hr reperfusionBlood glucose maintained at 300 mg/dL throughout procedureIn vivo substratesType I diabetesInfarction

Tanaka et al. (2002) [62]Dog, alloxan (40 mg/kg) and STZ (25 mg/kg)In vivo nonrecovery, 60 min regional ischemia/3 hr reperfusion3 weeksIn vivo substratesType I diabetesInfarction

Ravingerová et al. (2003) [53]Rat, STZ (45 mg/kg)In vivo nonrecovery, 30 min regional ischemia/4 hr reperfusion8 weeksIn vivo substratesType I diabetesInfarction

Ebel et al. (2003) [31]Rabbit- alloxan (100 mg/kg)In vivo nonrecovery, 30 min regional ischemia/2 hr reperfusion6 weeksIn vivo substratesType I diabetesInfarction

Desrois et al. (2004) [63]Aged Goto Kakisaki Rat, maleLangendorff isolated heart, 32 min low flow global ischemia/32 min reperfusionIn bred strain11 mmol/L glucoseType II diabetesMyocardial function

Ma et al. (2006) [56]Rat, STZ (50 mg/kg)In vivo nonrecovery, 30 min regional ischemia/2 hr reperfusion6 weeksIn vivo substratesType I diabetesInfarction

Bulhak et al. (2009) [64]Goto Kakizaki Rat, maleIn vivo nonrecovery, 35 min regional ischemia/2 hr reperfusionIn bred strainIn vivo substratesType II diabetesInfarction

Matsumoto et al. (2009) [65]Goto Kakizaki Rat, maleIn vivo nonrecovery, 30 min regional ischemia/2 hr reperfusionIn bred strainIn vivo substratesType II diabetesInfarction

Shi-Ting et al. (2011) [58]Rat, STZ (60 mg/kg)Langendorff isolated heart, 30 min regional ischemia/40 min reperfusion8 weeks11 mmol/L glucoseType I diabetesInfarction and creatine kinase release