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Disease Markers
Volume 20 (2004), Issue 3, Pages 131-134

Advancement of Biomarker Discovery and Validation through the HUPO Plasma Proteome Project

Gilbert S. Omenn

University of Michigan, A510 MSRB I, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0656, USA

Received 18 October 2004; Accepted 18 October 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Human Proteome Organization (HUPO) Plasma Proteome Project has mounted a Pilot Phase focussed on key problems essential for standardization of specimen collection, specimen handling, choice of fractionation and analysis technologies, and search engines and databases for protein identifications. This international collaboration will lay the groundwork for many large-scale clinical and epidemiological studies of health and disease.