A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

Table 4

The validation results in CA on the individual biomarker candidates of COPD in the human data and the CAs from the mouse data.

Individual protein or a panel of proteins	Optimal CA in			Belong to the general functional group^1
	Mouse BALF	Mouse plasma	Human plasma
Prothrombin, THRB	0.86	0.50	0.93	1–10
Vitamin D-binding protein, VTDB	0.69	0.63	0.86	2–10
Complement C3, CO3	0.69	0.67	0.79	1–10
Adiponectin, ADIPO	0.66	0.53	0.64	1–9
THRB; VTDB	0.97	0.57	0.93
THRB; CO3	0.86	0.70	0.93
VTDB; CO3	0.83	0.67	0.79
THRB; CO3; ADIPO	0.86	0.70	1.00
VTDB; CO3; ADIPO	0.83	0.70	0.93
THRB; VTDB; CO3; ADIPO	0.93	0.70	0.93

1The enriched functional clusters refer to the general functional groups listed in Table 2: 1: immune system process; 2: stress/stimulus response; 3: cellular response to stimulus; 4: metabolic process; 5: biological regulation; 6: death; 7: localization; 8: cellular organization; 9: proliferation; 10: others.