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Disease Markers
Volume 2016, Article ID 1243819, 8 pages
Review Article

Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus

1Clinical Hospital of Ophthalmologic Emergencies (SCUO), Piața Alexandru Lahovari 1, Bucharest, Romania
2Division of Ophthalmology, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania
3Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Sector 5, 050096 Bucharest, Romania
4Faculty of Medicine, Titu Maiorescu University, Dâmbovnicului Street 22, 040441 Bucharest, Romania
5Department of Ophthalmology, Charité University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany
6Division of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Victor Babes Street 8, 400012 Cluj-Napoca, Romania
7Clinical Emergency Hospital Cluj-Napoca, Clinicilor Street 3-5, 400006 Cluj-Napoca, Romania
8Department of Ophthalmology, University Emergency Hospital, Splaiul Independenței 169, 050098 Bucharest, Romania

Received 7 April 2016; Accepted 27 June 2016

Academic Editor: Simone Ribero

Copyright © 2016 Catalina Ionescu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.