Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population

Table 5

Analysis of EDN1 rs5370 and EDNRA rs5335 genotypic association with LAS in male and female subjects.

	Model	Pc	ORc (95% CI)	Pa	ORa (95% CI)
EDN1 rs5370
Female	Dominant	0.021	2.090 (1.119–3.903)	0.014	2.437 (1.202–4.940)
	Recessive	0.312	2.049 (0.511–8.218)	0.086	3.824 (0.828–17.667)
	Additive	0.034	2.008 (1.055–3.823)	0.042	2.135 (1.079–4.393)
		0.149	2.852 (0.681–11.827)	0.018	5.634 (1.157–27.436)
Male	Dominant	0.231	1.371 (0.818–2.297)	0.236	1.375 (0.812–2.330)
	Recessive	0.007	3.481 (1.404–8.635)	0.007	3.512 (1.401–8.806)
	Additive	0.939	1.022 (0.581–1.800)	0.952	1.018 (0.571–1.815)
		0.008	3.510 (1.382–8.913)	0.009	3.535 (1.377–9.076)
EDNRA rs5335
Female	Dominant	0.220	1.523 (0.778–2.981)	0.065	2.012 (0.956–4.230)
	Recessive	0.273	1.579 (0.698–3.572)	0.351	1.515 (0.633–3.629)
	Additive	0.352	1.398 (0.691–2.831)	0.105	1.921 (0.873–4.226)
		0.159	1.953 (0.770–4.952)	0.111	2.256 (0.829–6.136)
Male	Dominant	0.482	1.224 (0.696–2.153)	0.514	1.210 (0.682–2.148)
	Recessive	0.172	0.607 (0.297–1.242)	0.217	0.631 (0.304–1.310)
	Additive	0.257	1.405 (0.780–2.529)	0.299	1.373 (0.755–2.494)
		0.505	0.758 (0.336–1.710)	0.549	0.776 (0.339–1.777)

See Table 4; P_a: P value adjusted for age, body mass index, arterial hypertension, type 2 diabetes mellitus, and smoking.