Research Article
Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population
Table 6
Analysis of EDN1 rs5370 and EDNRA rs5335 genotypic association with LAS in subjects with and without arterial hypertension.
| | Model | Pc | ORc (95% CI) | Pa | ORa (95% CI) |
| | EDN1 rs5370 | | Nonhypertensive | Dominant | 0.262 | 1.500 (0.739–3.046) | 0.201 | 1.624 (0.773–3.411) | | Recessive | 0.125 | 2.572 (0.770–8.593) | 0.118 | 2.685 (0.778–9.269) | | Additive | 0.556 | 1.259 (0.584–2.714) | 0.470 | 1.348 (0.600–3.029) | | 0.104 | 2.800 (0.810–9.680) | 0.093 | 2.980 (0.834–10.650) | | Hypertensive | Dominant | 0.045 | 1.649 (1.011–2.689) | 0.036 | 1.711 (1.035–2.829) | | Recessive | 0.024 | 3.220 (1.164–8.903) | 0.008 | 4.102 (1.448–11.617) | | Additive | 0.188 | 1.411 (0.845–2.354) | 0.212 | 1.400 (0.825–2.374) | | 0.013 | 3.744 (1.322–10.607) | 0.004 | 4.743 (1.633–13.776) |
| | EDNRA rs5335 | | Nonhypertensive | Dominant | 0.170 | 1.793 (0.779–4.125) | 0.132 | 1.962 (0.817–4.717) | | Recessive | 0.443 | 1.457 (0.558–3.806) | 0.531 | 1.371 (0.512–3.672) | | Additive | 0.218 | 1.715 (0.727–4.048) | 0.159 | 1.909 (0.776–4.698) | | 0.196 | 2.127 (0.678–6.676) | 0.198 | 2.190 (0.664–7.221) | | Hypertensive | Dominant | 0.386 | 1.260 (0.747–2.126) | 0.271 | 1.353 (0.790–2.318) | | Recessive | 0.325 | 0.730 (0.390–1.366) | 0.317 | 0.718 (0.376–1.373) | | Additive | 0.214 | 1.420 (0.816–2.471) | 0.135 | 1.545 (0.873–2.735) | | 0.788 | 0.970 (0.445–1.850) | 0.864 | 0.938 (0.449–1.958) |
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See Table 4; Pa: P value adjusted for age, sex, body mass index, type 2 diabetes mellitus, and smoking. |
