High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients
Serum M30 levels in critically ill patients. (a) Serum levels of M30, at the time of admission to the ICU, were significantly higher in critically ill patients than in healthy controls (;U test). (b) M30 levels did not differ between ICU patients with or without sepsis. (c-d) M30 levels correlated with disease severity, as assessed by the APACHE II score (c) or serum concentrations of soluble urokinase plasminogen activator receptor (suPAR, d). (e-f) M30 levels in critically ill patients correlated with serum bilirubin (e) and were particularly elevated in ICU patients with liver cirrhosis (f).