Disease Markers / 2018 / Article / Tab 3

Research Article

High Circulating Caspase-Cleaved Keratin 18 Fragments (M30) Indicate Short-Term Mortality in Critically Ill Patients

Table 3

Correlations of clinical scores and laboratory parameters with M30 serum concentrations at admission day (Spearman rank correlation test, only significant results are shown).

ParametersICU patients

Disease severity
APACHE II score0.311<0.001
SOFA score0.390<0.001
SAPS2 score0.2900.018
Inflammation
Procalcitonin0.362<0.001
suPAR0.557<0.001
Interleukin-60.1630.023
TNF0.4410.002
Interleukin-100.369<0.001
LDH0.299<0.001
Renal function
Creatinine0.235<0.001
GFR (creatinine)−0.2240.003
Cystatin C0.292<0.001
GFR (cystatin C)−0.285<0.001
Urea0.1920.003
Uric acid0.1580.027
Liver function
Protein−0.269<0.001
Albumin−0.2120.015
Pseudocholinesterase−0.275<0.001
Bilirubin0.334<0.001
Bilirubin (conjugated)0.515<0.001
Gamma GT0.337<0.001
Alkaline phosphatase0.300<0.001
AST0.427<0.001
ALT0.358<0.001
GLDH0.466<0.001
INR0.402<0.001
Prothrombin time−0.391<0.001
aPTT0.389<0.001
D-dimers0.498<0.001
Antithrombin III−0.420<0.001
Platelets−0.1850.004

Nonsignificant correlations were noted for M30 levels with blood count, sodium, potassium, magnesium, amylase, lipase, creatine kinase, C-reactive protein, thyroid stimulating hormone, vitamin D, parameters of mechanical ventilation, and central venous pressure.