Disease Markers / 2019 / Article / Tab 1

Review Article

Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Table 1

Characteristics of the studies included in the meta-analysis.

AuthorYearCountryEthnicityFollow-up (months)TreatmentNo. of patientsStageCut-off valueSurvival analysisAnalysisConfounding factors adjusted forNOS score

Lee2015UKCaucasianNASurgery226Early1.8OSMVAge, grade, tumor size, NLR, PLR7
Zhang2015ChinaAsian50.8Mixed124Mixed4OSMVAge, sex, BMI, AC, concomitant Cis, T stage, LNM, DM, PLR8
Yoshida2015JapanAsian72 (27.6-111.6)Mixed181Mixed3.51OSMVT stage, N stage, grade, LVI, margin, AC, LVI7
Lucca2016AustriaCaucasianNASurgery310Early3.3OSMVT stage, grade, concomitant Cis, LVI, NLR, PLR, GPS, PNI6
D’Andrea2017AustriaCaucasian42.4 (18.3-85.1)Surgery4198Mixed3.5OS/RFS/CSSMVGender, age, margin, concomitant Cis, LNM, LVI, AC, NLR8
Miyake2017JapanAsian22 (10–64)Mixed117Mixed3.3OS/CSSUVNA6
Rajwa2018PolandCaucasian14 (7-40)Surgery144Mixed2.44OS/CSSMVT stage, LNM, grade, tumor necrosis, NLR, PLR8

Abbreviations: OS: overall survival; RFS: recurrence-free survival; CSS: cancer-specific survival; MV: multivariate; Cis: carcinoma in situ; AC: adjuvant chemotherapy; NLR: neutrophil-lymphocyte ratio; PLR: platelet-lymphocyte ratio; LNM: lymph node metastasis; DM: distant metastasis; LVI: lymphovascular invasion; GPS: Glasgow prognostic score; PNI: prognostic nutritional index; PMI: psoas muscle index; NA: not available.

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