Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Table 1

Characteristics of the studies included in the meta-analysis.

Author

Year

Country

Ethnicity

Follow-up (months)

Treatment

No. of patients

Stage

Cut-off value

Survival analysis

Analysis

Confounding factors adjusted for

NOS score

Temraz

2014

Lebanon

Caucasian

24

Mixed

68

Mixed

2.81

OS/RFS

UV

NA

8

Lee

2015

UK

Caucasian

NA

Surgery

226

Early

1.8

OS

MV

Age, grade, tumor size, NLR, PLR

7

Zhang

2015

China

Asian

50.8

Mixed

124

Mixed

4

OS

MV

Age, sex, BMI, AC, concomitant Cis, T stage, LNM, DM, PLR

8

Yoshida

2015

Japan

Asian

72 (27.6-111.6)

Mixed

181

Mixed

3.51

OS

MV

T stage, N stage, grade, LVI, margin, AC, LVI

7

Lucca

2016

Austria

Caucasian

NA

Surgery

310

Early

3.3

OS

MV

T stage, grade, concomitant Cis, LVI, NLR, PLR, GPS, PNI

6

D’Andrea

2017

Austria

Caucasian

42.4 (18.3-85.1)

Surgery

4198

Mixed

3.5

OS/RFS/CSS

MV

Gender, age, margin, concomitant Cis, LNM, LVI, AC, NLR

8

Miyake

2017

Japan

Asian

22 (10–64)

Mixed

117

Mixed

3.3

OS/CSS

UV

NA

6

Rajwa

2018

Poland

Caucasian

14 (7-40)

Surgery

144

Mixed

2.44

OS/CSS

MV

T stage, LNM, grade, tumor necrosis, NLR, PLR

8

Wang

2018

China

Asian

NA

Mixed

270

Early

4

RFS

UV

NA

7

Abbreviations: OS: overall survival; RFS: recurrence-free survival; CSS: cancer-specific survival; MV: multivariate; Cis: carcinoma in situ; AC: adjuvant chemotherapy; NLR: neutrophil-lymphocyte ratio; PLR: platelet-lymphocyte ratio; LNM: lymph node metastasis; DM: distant metastasis; LVI: lymphovascular invasion; GPS: Glasgow prognostic score; PNI: prognostic nutritional index; PMI: psoas muscle index; NA: not available.