Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Table 2

Pooled hazard ratios (HRs) for OS according to subgroup analyses.

Subgroup	No. of studies	No. of patients	HR (95% CI)	value	Heterogeneity
					(%)
Overall	8	5,368	0.63 (0.50-0.80)	<0.001	65.9	0.005
Ethnicity
Asian	2	422	0.46 (0.25-0.87)	0.016	73.3	0.023
Caucasian	5	4,946	0.80 (0.71-0.89)	<0.001	8.2	0.360
Disease stage
Early	2	536	0.61 (0.20-1.82)	0.377	0	0.705
Mixed	6	4,832	0.63 (0.49-0.80)	<0.001	75.3	0.001
Treatment
Surgery	4	4,878	0.81 (0.74-0.89)	<0.001	0	0.883
Mixed	4	482	0.45 (0.27-0.73)	0.001	62.3	0.047
Cut-off for LMR
≥3	5	4,930	0.56 (0.35-0.88)	0.011	76.6	0.002
<3	3	438	0.65 (0.41-1.04)	0.075	41.7	0.180
Analysis method
Univariate	2	185	0.46 (0.27-0.79)	0.005	0	0.488
Multivariate	6	5,183	0.67 (0.53-0.86)	0.001	65.9	0.005