Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China

Table 3

A piecewise linear regression model was applied to detect the association of Hcy and IS according to the Hcy cut points.

Outcome: incident of ischemic stroke	HR (95% CI)	value
Linear regression	1.13 (1.02 to 1.24)	<0.01
Two-piecewise linear regression model
	1.02 (0.97 to 1.07)	0.28
	1.35 (1.08 to 1.69)	<0.01
for the log-likelihood ratio test	<0.01

Notes: adjusted for age, gender, smoking status, drinking status, NC, WC, BMI, SBP, DBP, history of arrhythmia, diabetes, AHI, AI, HI, sleep duration, mean SaO2 and lowest SaO2, antidiabetic drugs, antiplatelet drugs, lipid-lowering drugs, regular CPAP treatment, antihypertensive drugs, and TC, TG, HDL-c, LDL-c, FPG, eGFR, Cr, and hs-CRP levels at baseline. Abbreviations are the same as in Table 1.