Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China

Table 4

Association between Hcy and the first IS in various subgroups.

Stratification variable	No. of participants.	HR (95% CI)	95% CI low	95% CI high	value	for interaction
Gender						0.63
Female	744	1.20	0.65	2.22	0.56
Male	1606	1.40	1.13	1.74	<0.01
Diabetes						0.51
No	1937	1.39	1.12	1.73	<0.01
Yes	413	1.16	0.70	1.92	0.57
Arrhythmia						0.18
No	2306	1.24	1.05	1.46	0.01
Yes	440	1.41	1.27	1.57	<0.01
Smoking status						0.63
Never	1342	1.33	0.94	1.88	0.10
Former	258	1.78	1.04	3.05	0.04
Current	750	1.34	0.99	1.80	0.05
Drinking status						0.65
Never	1557	1.43	1.12	1.82	<0.01
Former	166	1.24	0.63	2.46	0.54
Current	627	1.13	0.72	1.79	0.59
Age (years)						0.87
<60	1911	1.36	1.07	1.73	0.01
≥60	439	1.42	0.96	2.08	0.08
BMI (kg/m^2)						0.03
<24	221	1.13	0.95	1.33	0.16
≥24, <28	934	1.46	1.26	1.70	<0.01
≥28	1195	1.46	1.25	1.70	<0.01
SBP (mmHg)						0.41
<140	1084	1.25	0.86	1.82	0.23
≥140	1266	1.51	1.18	1.92	<0.01
DBP (mmHg)						0.04
<90	887	1.20	1.02	1.42	0.03
≥90	1463	1.48	1.33	1.65	<0.01
AHI (events/hour)						0.37
≥5, <15	934	1.46	1.04	2.07	0.03
≥15, <30	722	1.47	1.04	2.09	0.03
≥30	694	1.07	0.73	1.56	0.74
FPG (mmol/L)						0.72
<6.1	1991	1.38	1.23	1.54	<0.01
≥6.1	359	1.32	1.04	1.66	0.02
eGFR (mL/min/1.73 m^2)						0.59
<90	941	1.42	1.08	1.85	0.01
≥90	1409	1.27	0.93	1.72	0.13

Note 1: adjusted for age, gender, smoking status, drinking status, NC, WC, BMI, SBP, DBP, history of arrhythmia, diabetes, AHI, AI, HI, sleep duration, mean SaO₂ and lowest SaO₂, antidiabetic drugs, antiplatelet drugs, lipid-lowering drugs, regular CPAP treatment, antihypertensive drugs, and TC, TG, HDL-c, LDL-c, FPG, eGFR, Cr, and hs-CRP levels at baseline. Note 2: in each case, the model was not adjusted for hierarchical covariates. Abbreviations are the same as in Table 1.