diffus optic tomographi dot emerg viabl new biomed imag modal using nearinfrar nir light techniqu probe absorpt well scatter properti biolog tissu first commerci instrument now avail allow user obtain crosssect volumetr view various bodi part current main applic brain breast limb joint fluoresc bioluminesc imag although spatial resolut limit when compar other imag modal magnet reson imag mri xray computer tomographi dot provid access varieti physiolog paramet otherwis access includ subsecond imag hemodynam other fastchang process furthermor dot can realiz compact portabl instrument allow bedsid monitor relat low cost paper present overview current stateofth art technolog includ hardwar imagereconstruct algorithm focus applic brain joint imag addit present recent result work optic tomograph imag small anim

A. H. Hielscher

A. Y. Bluestone

G. S. Abdoulaev

A. D. Klose

J. Lasker

M. Stewart

U. Netz

J. Beuthan

Near-Infrared Diffuse Optical Tomography

Barbara Y. Croft

Foreword

identifi physiolog anatom signatur diseas signal imag one fundament challeng biomed engin the challeng most appar given signatur must identifi spite tremend inter intrasubject variabl nois crucial uncov signatur has been develop method exploit general statist properti natur signal the signal process appli mathemat communiti have develop recent year signal represent which take advantag gabortyp wavelettyp function local signal energi joint timefrequ spacefrequ domain these techniqu can express multiresolut transform which perhap best known wavelet transform paper review wavelet other relat multiresolut transform within context identifi signatur diseas these transform construct general represent signal which can use detect diagnosi treatment monitor present sever exampl where transform appli biomed signal imag process these includ computeraid diagnosi mammographi realtim mosaick ophthalm slitlamp imageri character heart diseas via ultrasound predict epilept seizur signatur analysi electroencephalogram reconstruct positron emiss tomographi data

Paul Sajda

Andrew Laine

Yehoshua Zeevi

Multi-Resolution and Wavelet Representations for Identifying Signatures of Disease

animal model can use studi diseas this chapter discuss imag anim model elucid process human diseas the mous use primari model though choic simplifi mani research choic necessit compromis vivo imag futur can expect improv both anim model imag techniqu

Animal Models for imaging

ultrasound has been popular clinic imag modal decad well establish mean display macroscop anatomi softtissu structur while convent ultrasound methodolog bmode doppler method well proven continu advanc technic daili basi extend higher frequenc take advantag harmon phenomena tissu fundament new ultrasound technolog also emerg offer excit promis make signific improv clinic imag diseas these emerg method includ spectrum analysi elast imag contrastag method advanc flow detect measur techniqu each provid independ inform use alon each can provid power new imag capabl combin each other capabl may even greater mani applic all principl can use concert other imag modal offer possibl further improv diseas detect evalu monitor

Ernest J. Feleppa

S. Kaisar Alam

Cheri X. Deng

Emerging Ultrasound Technologies for Early Markers of Disease

vivo endoscop optic microscopi provid tool assess tissu architectur morpholog contrast resolut similar provid standard histopatholog without need physic tissu remov articl focus optic imag technolog have potenti dramat improv detect prevent therapi epitheli cancer epitheli precanc cancer associ varieti morpholog architectur molecular chang which current can assess onli through invas pain biopsi optical imag ideal suit detect cancerrel alter becaus can detect biochem morpholog alter subcellular resolut throughout entir epitheli thick optical techniqu can implement noninvas real time low cost survey tissu surfac risk our manuscript focus primarili modal current most develop reflect confoc microscopi rcm optic coher tomographi oct howev recent advanc fluorescencebas endoscop microscopi also review briefli discuss basic principl emerg technolog current potenti applic earli cancer detect also present research activ focus develop exogen contrast agent can enhanc morpholog featur import cancer detect have potenti allow vital molecular imag cancerrel biomark conclus discuss futur improv technolog need develop robust clinic devic

Konstantin Sokolov

Kung-Bin Sung

Tom Collier

Anne Clark

Dizem Arifler

Alicia Lacy

Michael Descour

Rebecca Richards-Kortum

Endoscopic Microscopy

the purpos report present overview use fluoresc imag vivo particular emphasi oncolog import note howev mani method describ herein have been appli studi nonmalign tissu well modern medicin biolog research has benefit great from everexpand assort fluoresc marker label these marker label have allow investig observ behavior properti cell molecular entiti interest context complic biolog system mammalian cell whole mous method develop imag fluoresc whole mice have been valuabl studi pattern tumor growth metastas alternat more detail inform wide varieti endpoint can obtain use intravit prepar this review focus use fluoresc imag intravit prepar for detail fluoresc imag whole anim refer review subject 12 for oncolog applic studi have focus primarili window chamber prepar allow realtim visual tumor growth vascular vascular respons stimul vascular permeabl vascular orient flow instabl like these endpoint have been use show function differ between tumor normal tissu respect function under baselin condit after therapeut manipul exampl some differ provid review mean illustr how can use

Mark W. Dewhirst

S. Shan

Yiting Cao

Benjamin Moeller

Fan Yuan

Chuan-Yuan Li

Intravital Fluorescence Facilitates Measurement of Multiple Physiologic Functions and Gene Expression in Tumors of Live Animals

positron emiss tomographi pet provid power mean noninvas imag quantifi protein express biochem chang live subject nano picomolar level field molecular imag develop advanc biochemistri pharmacolog therapeut molecular biolog diseas made correspond increas number clinic relev novel diseaseassoci biomark brought attent those develop imag probe pet addit due high specif pet radiotrac be develop demand pet camera higher sensit resolut this manuscript review advanc over past five year clinic preclin pet instrument new pet probe imag method associ latest trend molecular imag cancer include pet tracer review descript new radioligand steroid receptor growth factor receptor receptor tyrosin kinas sigma receptor tumorassoci enzym gene report probe marker tumor hypoxia metabol site associ angiogenesi cellular prolifer the use pet imag drug develop includ monitor cancer chemotherapi also discuss

T. Lee Collier

Roger Lecomte

Timothy J. McCarthy

Steve Meikle

Thomas J. Ruth

Francesco Scopinaro

Alberto Signore

Henry Van Brocklin

Christophe Van de Wiele

Rikki N. Waterhouse

Assessment of Cancer-Associated Biomarkers by Positron Emission Tomography: Advances and Challenges

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Disease Markers publishes papers related to the identification of disease markers, the elucidation of their role and mechanism, as well as their application in the prognosis, diagnosis and treatment of diseases.

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