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| Sr. number | Clinical manifestations | Preferred treatment [dose] | Alternative treatment | Remarks |
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| 1 | Uncomplicated cutaneous sporotrichosis | Itraconazole [200 mg/day] | Itraconazole [200 mg b.i.d.] or terbinafine [500 mg b.i.d.] or SSKI [increasing doses] or fluconazole [400–800 mg/day] or local hyperthermia | Treatment for 2–4 weeks after lesions have resolved |
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| 2 | Osteoarticular sporotrichosis | Itraconazole [200 mg twice daily (b.i.d.)] | Liposomal amphotericin B (3–5 mg/kg/day) or deoxycholate amphotericin B [0.7–1 mg/kg/day] until resolution | Switching to itraconazole after resolution and treatment for a total of 12 months |
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| 3 | Pulmonary sporotrichosis | Liposomal amphotericin B [3–5 mg/kg/day] and then itraconazole [200 mg b.i.d.] | Deoxycholate amphotericin B [0.7–1 mg/kg/day] until recovery and then itraconazole [200 mg b.i.d.] | Treating less severe disease with itraconazole. Treatment for at least 12 months |
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| 4 | Meningeal sporotrichosis | Liposomal Amphotericin B [3–5 mg/kg/day] and then itraconazole [200 mg b.i.d.] | Deoxycholate amphotericin B [0.7–1 mg/kg/day] until recovery and then itraconazole [200 mg b.i.d.] | Length of therapy with amphotericin B is not established. Treatment for 4–6 weeks and total of 12 months. Suppressive therapy with itraconazole is needed |
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| 5 | Disseminated sporotrichosis | Liposomal amphotericin B [3–5 mg/kg/day] and then itraconazole [200 mg b.i.d.] | Deoxycholate amphotericin B [0.7–1 mg/kg/day] until recovery and then Itraconazole [200 mg b.i.d.] | Treatment with amphotericin B until objective improvement and for at least 12 months. Suppressive therapy with itraconazole is needed |
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| 6 | Sporotrichosis in pregnant women |
Treating only severe sporotrichosis with liposomal amphotericin B [3–5 mg/kg/day] or deoxycholate amphotericin B [0.7–1 mg/kg/day].
Treatment with local hyperthermia [approx. 45°C] for uncomplicated cutaneous sporotrichosis | Preferably, defer treatment for uncomplicated cases |
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| 7 | Sporotrichosis in children | Itraconazole [6–10 mg/kg/d or maximum of 400 mg/day] for mild disease, deoxycholate amphotericin B [0.7–1 mg/kg/day] for severe disease | SSKI with increasing doses equivalent to half the adult dose for a duration as in adults | Treating severe disease with an amphotericin B formulation |
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