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Research Article
Dermatology Research and Practice
Volume 2015 (2015), Article ID 429429, 2 pages
Letter to the Editor

Comment on “Metabolic Changes and Serum Ghrelin Level in Patients with Psoriasis”

1Department of Biochemistry, Agri Military Hospital, 04100 Agri, Turkey
2Department of Biochemistry, Sirnak Military Hospital, 73010 Sirnak, Turkey
3Department of Medical Biochemistry, Gulhane Military Medical Academy, 06018 Ankara, Turkey

Received 5 February 2015; Accepted 15 April 2015

Academic Editor: Kiyofumi Yamanishi

Copyright © 2015 Mehmet Agilli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Thanks are due to Dr. Ucak and colleagues for their valuable research evaluating the levels of serum ghrelin in patients with psoriasis [1]. However, we wish to make some comments on methodology of their study.

Ghrelin is a hormone secreted mainly by stomach. Some types of antipsychotics, antidepressants, corticosteroids, bromocriptine, and anti-TNF-α therapy drugs were suggested to affect serum ghrelin levels [2, 3]. Also, dietary food supplements such as vitamin D and free fatty acids could affect these levels [4]. In this respect, the authors should define whether the participants use these kinds of drugs and dietary supplements or not.

In addition, several studies revealed that certain diseases such as functional dyspepsia, celiac disease, cachexia, inflammatory bowel disease, asthma, ankylosing spondylitis, coronary artery disease, iron deficiency anemia, hepatocellular cancer, chronic liver disease, chronic renal disease, epilepsy, and Helicobacter pylori infection could affect serum ghrelin [5, 6]. The authors did not mention these contributing diseases in their paper.

Ucak and colleagues stated that they questioned the patients’ alcohol and cigarette smoking habits. As known, serum ghrelin levels are associated with alcohol intake and smoking [7, 8]. In this regard, a regression analysis could be applied for these variables to examine whether they affect serum ghrelin levels. Therefore, interpretation of results with its current form seems problematic.

In conclusion, we believe that the study of Ucak et al. contributes important data to medical literature and could lead other researchers to design a study. However clarifying above concerns will provide clearer picture to the readers.

Conflict of Interests

The authors declare no conflict of interests.


  1. H. Ucak, B. Demir, D. Cicek et al., “Metabolic changes and serum ghrelin level in patients with psoriasis,” Dermatology Research and Practice, vol. 2014, Article ID 175693, 6 pages, 2014. View at Publisher · View at Google Scholar
  2. B. Otto, M. Tschöp, W. Heldwein, A. F. H. Pfeiffer, and S. Diederich, “Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans,” European Journal of Endocrinology, vol. 151, no. 1, pp. 113–117, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Esen-Danaci, A. Sarandöl, F. Taneli, F. Yurtsever, and N. Özlen, “Effects of second generation antipsychotics on leptin and ghrelin,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 6, pp. 1434–1438, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. L. C. Gormsen, J. Gjedsted, S. Gjedde et al., “Free fatty acids decrease circulating ghrelin concentrations in humans,” European Journal of Endocrinology, vol. 154, no. 5, pp. 667–673, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. M. S. Berilgen, B. Mungen, B. Ustundag, and C. Demir, “Serum ghrelin levels are enhanced in patients with epilepsy,” Seizure, vol. 15, no. 2, pp. 106–111, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Dogan, B. Alioglu, N. Dindar, and Y. Dallar, “Increased serum hepcidin and ghrelin levels in children treated for iron deficiency anemia,” Journal of Clinical Laboratory Analysis, vol. 27, no. 1, pp. 81–85, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Bouros, A. Tzouvelekis, S. Anevlavis et al., “Smoking acutely increases plasma ghrelin concentrations,” Clinical Chemistry, vol. 52, no. 4, pp. 777–778, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Makovey, V. Naganathan, M. Seibel, and P. Sambrook, “Gender differences in plasma ghrelin and its relations to body composition and bone—an opposite-sex twin study,” Clinical Endocrinology (Oxford), vol. 66, no. 4, pp. 530–537, 2007. View at Publisher · View at Google Scholar · View at Scopus