A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats
KXS restores the decreased level of neurotransmitters in depressive rats. The treatment of KXS in the rats was as that in Figure 2. The total brain was collected after the treatment. The amounts of dopamine, norepinepherine, serotonin, and 5-HIAA in rat brains were analyzed by LC-MS. Two doses of KXS were applied including low dosage at 0.9 g/kg (KXS-L) and high dosage at 2.7 g/kg (KXS-H). The imipramine at dose of 20 mg/kg was set as the positive control. Values are showed as the mean ± SEM (). * **.