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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 176385, 7 pages
http://dx.doi.org/10.1155/2012/176385
Research Article

Effect of Methanolic Leaf Extract of Ocimum basilicum L. on Benzene-Induced Hematotoxicity in Mice

1Cytogenetics & Plant Biotechnology Research Unit, Department of Botany, University of Kalyani, Nadia, Kalyani 741235, India
2Cytogenetics & Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Nadia, Kalyani 741235, India

Received 18 May 2012; Revised 13 July 2012; Accepted 26 July 2012

Academic Editor: Senthamil R. Selvan

Copyright © 2012 S. Saha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. D. McChesney, S. K. Venkataraman, and J. T. Henri, “Plant natural products: back to the future or into extinction?” Phytochemistry, vol. 68, no. 14, pp. 2015–2022, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Bailly, “Ready for a comeback of natural products in oncology,” Biochemical Pharmacology, vol. 77, no. 9, pp. 1447–1457, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. D. S. Seigler, Plant Secondary Metabolism, Kluwer Academic, Boston, Mass, USA, 1998.
  4. J. B. Harborne, “Arsenal for survival: secondary plant products,” Taxon, vol. 49, no. 3, pp. 435–449, 2000. View at Google Scholar · View at Scopus
  5. D. J. McGarvey and R. Croteau, “Terpenoid metabolism,” Plant Cell, vol. 7, no. 7, pp. 1015–1026, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Schulz, F. Uhling, and S. Ansorge, “Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene and related monoterpenes,” European Journal of Immunology, vol. 24, no. 2, pp. 301–307, 1994. View at Google Scholar · View at Scopus
  7. P. L. Crowell, C. E. Elson, H. H. Bailey, A. Elegbede, J. D. Haag, and M. N. Gould, “Human metabolism of the experimental cancer therapeutic agent d-limonene,” Cancer Chemotherapy and Pharmacology, vol. 35, no. 1, pp. 31–37, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. S. G. Yu, L. A. Hildebrandt, and C. E. Elson, “Geraniol, an inhibitor of mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas transplanted to rats and mice,” Journal of Nutrition, vol. 125, no. 11, pp. 2763–2767, 1995. View at Google Scholar · View at Scopus
  9. P. L. Crowell, “Prevention and therapy of cancer by dietary monoterpenes,” Journal of Nutrition, vol. 129, no. 3, pp. 775S–778S, 1999. View at Google Scholar
  10. S. K. Jaganathan, A. Mazumdar, D. Mondhe, and M. Mandal, “Apoptotic effect of eugenol in human colon cancer cell lines,” Cell Biology International, vol. 35, no. 6, pp. 607–615, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. M. A. Morse and G. D. Stoner, “Cancer chemoprevention: principles and prospects,” Carcinogenesis, vol. 14, no. 9, pp. 1737–1746, 1993. View at Google Scholar · View at Scopus
  12. J. P. Brown, “A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds,” Mutation Research, vol. 75, no. 3, pp. 243–277, 1980. View at Google Scholar · View at Scopus
  13. S. J. Lee, K. Umano, T. Shibamoto, and K. G. Lee, “Identification of volatile components in basil (Ocimum basilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties,” Food Chemistry, vol. 91, no. 1, pp. 131–137, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. R. S. Deshpande and H. P. Tipnis, “Insecticidal activity of Ocimum basilicum L.,” Pesticides, vol. 11, pp. 11–12, 1977. View at Google Scholar
  15. J. E. Simon, J. Quinn, and R. G. Murray, “Basil: a source of essential oils,” in Advances in New Crops, J. Janick and J. E. Simon, Eds., pp. 484–489, Timber, Portland, Ore, USA, 1999. View at Google Scholar
  16. H. R. Juliani and J. E. Simon, “Antioxidant activity of basil,” in Trends in New Crops and New Uses, J. Janic and A. Whipkey, Eds., pp. 575–579, ASHS Press, Alexandria, Va, USA, 2002. View at Google Scholar
  17. A. Caceres, O. Cano, B. Samayoa, and L. Aguilar, “Plants used in Guatemala for the treatment of gastrointestinal disorders. 1. Screening of 84 plants against enterobacteria,” Journal of Ethnopharmacology, vol. 30, no. 1, pp. 55–73, 1990. View at Publisher · View at Google Scholar · View at Scopus
  18. K. A. Qamar, A. Dar, B. S. Siddiqui et al., “Anticancer activity of Ocimum basilicum and the effect of ursolic acid on the cytoskeleton of MCF-7 human breast cancer cells,” Letters in Drug Design and Discovery, vol. 7, no. 10, pp. 726–736, 2010. View at Google Scholar · View at Scopus
  19. M. Carballo, M. L. Nigro, I. Fraga, and A. Gadano, “Ethylene oxide: cytogenetic and biochemical studies in persons occupationally exposed,” Environmental and Molecular Mutagenesis, vol. 23, pp. 7–12, 1994. View at Google Scholar
  20. G. K. Raabe and O. Wong, “Leukemia mortality by cell type in petroleum workers with potential exposure to benzene,” Environmental Health Perspectives, vol. 104, no. 6, pp. 1381–1392, 1996. View at Google Scholar · View at Scopus
  21. M. Aksoy, S. Erdem, and G. DinCol, “Leukemia in shoe workers exposed chronically to benzene,” Blood, vol. 44, no. 6, pp. 837–841, 1974. View at Google Scholar · View at Scopus
  22. C. A. Snyder, B. D. Goldstein, and A. R. Sellakumar, “The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57BL/6J mice,” Toxicology and Applied Pharmacology, vol. 54, no. 2, pp. 323–331, 1980. View at Google Scholar · View at Scopus
  23. A. I. Vogel, Textbook of Practical Organic Chemistry, The English Language Book Society and Longman, London, UK, 1978.
  24. J. N. Kasolo, G. S. Bimenya, L. Ojok, and J. W. Ogwal-okeng, “Phytochemicals and acute toxicity of Moringa oleifera roots in mice,” Journal of Pharmacognosy and Phytotherapy, vol. 3, pp. 38–42, 2011. View at Google Scholar
  25. V. Sharma and D. Pandey, “Beneficial effects of Tinospora cordifolia on blood profiles in male mice exposed to lead,” Toxicology International, vol. 17, no. 1, pp. 8–11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. B. I. Yoon, Y. Hirabayashi, Y. Kawasaki et al., “Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM),” Experimental Hematology, vol. 29, no. 3, pp. 278–285, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Google Scholar · View at Scopus
  28. R. J. Grayer, G. C. Kite, F. J. Goldstone, S. E. Bryan, A. Paton, and E. Putievsky, “Infraspecific taxonomy and essential oil chemotypes in sweet basil, Ocimum basilicum,” Phytochemistry, vol. 43, no. 5, pp. 1033–1039, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Marotti, R. Piccaglia, and E. Giovanelli, “Differences in essential oil composition of basil (Ocimum basilicum L.) Italian cultivars related to morphological characteristics,” Journal of Agricultural and Food Chemistry, vol. 44, no. 12, pp. 3926–3929, 1996. View at Google Scholar · View at Scopus
  30. J. C. Chalchat, R. P. Garry, L. Sidibé, and M. Harama, “Aromatic plants of Mali (I): chemical composition of essential oils of Ocimum basilicum L.,” Journal of Essential Oil Research, vol. 11, no. 3, pp. 375–380, 1999. View at Google Scholar · View at Scopus
  31. L. Mondello, G. Zappia, A. Cotroneo et al., “Studies on the chemical oil-bearing plants of Bangladesh. Part VIII. Composition of some Ocimum oils, O. basilicum L. var. purpurascens; O. sanctum L. green; O. sanctum L. purple; O. americanum L., citral type; O. americanum L., camphor type,” Flavour and Fragrance Journal, vol. 17, no. 5, pp. 335–340, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. G. M. Farris, S. N. Robinson, K. W. Gaido et al., “Benzene-induced hematotoxicity and bone marrow compensation in B6C3F1 mice,” Toxicological Sciences, vol. 36, no. 2, pp. 119–129, 1997. View at Google Scholar · View at Scopus
  33. M. B. Kastan and J. Bartek, “Cell-cycle checkpoints and cancer,” Nature, vol. 432, no. 7015, pp. 316–323, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Vermeulen, D. R. Van Bockstaele, and Z. N. Berneman, “The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer,” Cell Proliferation, vol. 36, no. 3, pp. 131–149, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Satyanarayana and P. Kaldis, “Mammalian cell-cycle regulation: several cdks, numerous cyclins and diverse compensatory mechanisms,” Oncogene, vol. 28, no. 33, pp. 2925–2939, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. K. D. Park, S. G. Lee, S. U. Kim et al., “Anticancer activity of 3-O-acyl and alkyl-(-)-epicatechin derivatives,” Bioorganic and Medicinal Chemistry Letters, vol. 14, no. 20, pp. 5189–5192, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. A. M. Abukhdeir and B. H. Park, “p21 and p27: roles in carcinogenesis and drug resistance,” Expert Reviews in Molecular Medicine, vol. 10, article e19, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Olson, G. Betton, D. Robinson et al., “Concordance of the toxicity of pharmaceuticals in humans and in animals,” Regulatory Toxicology and Pharmacology, vol. 32, no. 1, pp. 56–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. O. W. Schalm, N. C. Jain, and E. C. J. Carroll, Veterinary Hematology, Lea and Febiger, Philadelphia, Pa, USA, 3rd edition, 1975.
  40. E. P. Cronkite, R. T. Drew, T. Inoue, Y. Hirabayashi, and J. E. Bullis, “Hematotoxicity and carcinogenicity of inhaled benzene,” Environmental Health Perspectives, vol. 82, pp. 97–108, 1989. View at Google Scholar · View at Scopus