Oroxylin A, but Not Vasopressin, Ameliorates Cardiac Dysfunction of Endotoxemic Rats
Figure 4
Effects of Oro-A and AVP on the HR of isolated hearts from endotoxemic rats. The representative tracings in (a) and (b) indicate that Oro-A (10 μM) perfusion does not affect the HR in either constant pressure or constant flow heart preparation from 5 hr post-LPS rats. AVP (0.2 IU/L) perfusion, however, decreases HR in constant pressure heart preparation but does not affect that in constant flow heart preparation. The bar chart in (a) summarizes effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on HR in constant pressure heart preparation from 5 hr or 16 hr post-LPS rats. The bar chart in (b) summarizes effects of Oro-A (10 and 20 μM, solid bar) and AVP (0.2 and 0.4 IU/L, open bar) on HR in constant flow heart preparation from 5 hr or 16 hr post-LPS rats. Values of normal control, and 5 hr and 16 hr post-LPS rats are from Table 1. Values are mean ± SEM ( each group). * versus respective LPS groups; # versus normal control; † versus 5 hr post-LPS group. HR (heart rate).
