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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 561284, 10 pages
http://dx.doi.org/10.1155/2012/561284
Research Article

Antioxidant Activity and Hepatoprotective Potential of Polyalthia longifolia and Cassia spectabilis Leaves against Paracetamol-Induced Liver Injury

1Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia (USM), Gelugor, 11800 Penang, Malaysia
2Dental Research & Training Unit and Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 2 June 2012; Revised 12 September 2012; Accepted 4 October 2012

Academic Editor: DaoFeng Chen

Copyright © 2012 Subramanion L. Jothy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [15 citations]

The following is the list of published articles that have cited the current article.

  • Kuppan Nithianantham, Kwan Yuet Ping, Lachimanan Yoga Latha, Subramanion L Jothy, Ibrahim Darah, Yeng Chen, Ai-Lan Chew, and Sreenivasan Sasidharan, “Evaluation of hepatoprotective effect of methanolic extract of Clitoria ternatea (Linn.) flower against acetaminophen-induced liver damage,” Asian Pacific Journal of Tropical Disease, vol. 3, no. 4, pp. 314–319, 2013. View at Publisher · View at Google Scholar
  • Subramanion L. Jothy, Yeng Chen, Jagat R. Kanwar, and Sreenivasan Sasidharan, “Evaluation of the Genotoxic Potential against -Radical-Mediated DNA Damage and Acute Oral Toxicity of Standardized Extract of Polyalthia longifolia Leaf,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–13, 2013. View at Publisher · View at Google Scholar
  • Masayuki Ninomiya, Adlis Santoni, Kaori Tanaka, Mamoru Koketsu, Dina Permata Sari, Mai Efdi, and Sanusi Ibrahim, “Clerodane diterpenes isolated from Polyalthia longifolia induce apoptosis in human leukemia HL-60 cells,” Journal of Oleo Science, vol. 62, no. 10, pp. 843–848, 2013. View at Publisher · View at Google Scholar
  • Gustavo Henrique da Silva, Pedro Paulo Barros, Gisele Mara Silva Gonçalves, and Matheus Arnosti Landi, “Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats,” Homeopathy, 2014. View at Publisher · View at Google Scholar
  • Xiao-Xin Chen, Ge Liang, Wei-Ming Chai, Hui-Ling Feng, Han-Tao Zhou, Yan Shi, and Qing-Xi Chen, “Antioxidant and antityrosinase proanthocyanidins from Polyalthia longifolia leaves,” Journal of Bioscience and Bioengineering, 2014. View at Publisher · View at Google Scholar
  • Muheeb Beg, Kripa Shankar, Salil Varshney, Sujith Rajan, Suriya Pratap Singh, Pankaj Jagdale, Anju Puri, Bhushan P. Chaudhari, Koneni V. Sashidhara, and Anil Nilkanth Gaikwad, “A clerodane diterpene inhibit adipogenesis by Cell cycle arrest and ameliorate obesity in C57BL/6 mice,” Molecular and Cellular Endocrinology, 2014. View at Publisher · View at Google Scholar
  • Hemant D. Une, and Gaurav Mahesh Doshi, “In vitro cytotoxicity studies on Carissa congesta, Polyalthia longifolia, and Benincasa hispida extracts by Sulforhodamine B assay method,” International Journal of Green Pharmacy, vol. 9, no. 3, pp. 157–161, 2015. View at Publisher · View at Google Scholar
  • Gaurav Mahesh Doshi, and Hemant Devidas Une, “Screening of Polyalthia longifolia Leaves as Potential Immunomodulatory Target,” International Journal Of Pharmacology, vol. 11, no. 2, pp. 106–113, 2015. View at Publisher · View at Google Scholar
  • Carolina Hernández-Castro, Fredyc Diaz-Castillo, and Marlen Martínez-Gutierrez, “Ethanol extracts of Cassia grandis and Tabernaemontana cymosa inhibit the in vitro replication of dengue virus serotype 2,” Asian Pacific Journal of Tropical Disease, vol. 5, no. 2, pp. 98–106, 2015. View at Publisher · View at Google Scholar
  • Sha Li, Hor-Yue Tan, Ning Wang, Zhang-Jin Zhang, Lixing Lao, Chi-Woon Wong, and Yibin Feng, “The Role of Oxidative Stress and Antioxidants in Liver Diseases,” International Journal Of Molecular Sciences, vol. 16, no. 11, pp. 26087–26124, 2015. View at Publisher · View at Google Scholar
  • Subramanion L. Jothy, Tamio Saito, Jagat R. Kanwar, Yeng Chen, Azlan Aziz, Leong Yin-Hui, and Sreenivasan Sasidharan, “Radioprotective activity of Polyalthia longifolia standardized extract against X-ray radiation injury in mice,” Physica Medica, 2015. View at Publisher · View at Google Scholar
  • Bharat Singh, Pooran M. Sahu, and Ram A. Sharma, “Flavonoids from Heliotropium subulatum exudate and their evaluation for antioxidant, antineoplastic and cytotoxic activities II,” Cytotechnology, 2016. View at Publisher · View at Google Scholar
  • Xu Wang, Qinghua Wu, Aimei Liu, Arturo Anadón, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan, and María-Aránzazu Martínez, “ Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro ,” Drug Metabolism Reviews, pp. 1–43, 2017. View at Publisher · View at Google Scholar
  • Yavar Mahmoodzadeh, Mohammad Mazani, and Lotfollah Rezagholizadeh, “Hepatoprotective Effect of Methanolic Tanacetum Parthenium Extract on CCl4-Induced Liver Damage in Rats,” Toxicology Reports, 2017. View at Publisher · View at Google Scholar
  • Soundararajan Vijayarathna, Chern Ein Oon, Yeng Chen, Jagat R. Kanwar, and Sreenivasan Sasidharan, “Polyalthia longifolia Methanolic Leaf Extracts (PLME) induce apoptosis, cell cycle arrest and mitochondrial potential depolarization by possibly modulating the redox status in hela cells,” Biomedicine & Pharmacotherapy, vol. 89, pp. 499–514, 2017. View at Publisher · View at Google Scholar