Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China

Table 1

Effect of phenolic compounds-rich fraction from Urtica atrichocaulis (TFUA) on FCA-induced rats arthritis.

Group	Dose (mg/kg)	Paw swell (mm)						Arthritis index
		12 d		16 d		20 d		12 d	16 d	20 d
		R	L	R	L	R	L
Vehicle	—	4.21  ±  0.84	3.52  ±  1.01	3.86  ±  0.72	3.63  ±  0.71	3.47  ±  0.45	3.29  ±  0.73	7.6  ±  2.1	9.9  ±  2.6	10.3  ±  1.9
Dexamethasone	30	3.34  ±  0.66*	2.61  ±  0.76*	3.09  ±  0.56*	2.52  ±  0.76**	2.88  ±  0.27**	2.07  ±  0.62**	5.2  ±  2.3*	4.4  ±  1.8**	3.5  ±  2.7**
TFUA	50	3.77  ±  0.75	3.07  ±  0.94	3.61  ±  0.62	2.82  ±  0.97*	3.02  ±  0.46*	2.52  ±  0.56*	7.1  ±  1.9	8.7  ±  1.5	8.4  ±  2.3
	150	3.51  ±  0.61*	2.89  ±  0.85*	3.20  ±  0.67*	2.77  ±  0.85*	2.81  ±  0.61*	2.27  ±  0.68**	6.5  ±  2.0	7.8  ±  1.5*	7.6  ±  2.2*

Values are expressed as mean ± SD. N  =  10. *P  <  0.05, **P  <  0.01 compared with vehicle control.