Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 6

Research Article

Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China

Table 6

The antirheumatoid arthritis activities of the main phenolic compounds and their combination.

GroupDose (mg/kg)Paw swell (mm)Arthritis index
12 d16 d20 d12 d16 d20 d
RLRLRL

Vehicle4.45  ±  0.933.80  ±  0.614.16  ±  0.894.03  ±  0.773.89  ±  0.543.57  ±  0.618.5  ±  2.310.8  ±  1.711.1  ±  2.4
Dexamethasone303.33  ±  0.65*3.09  ±  0.87*2.92  ±  0.72**2.84  ±  0.47**2.23  ±  0.42**2.24  ±  0.58**6.2  ±  1.7*4.9  ±  1.8**3.7  ±  2.7**
Salicylic acid503.57  ±  0.89*3.67  ±  0.793.34  ±  0.56*3.51  ±  0.832.95  ±  0.61*3.25  ±  0.437.7  ±  2.810.1  ±  2.59.8  ±  1.7
Phaselic acid503.88  ±  0.893.52  ±  0.853.09  ±  0.67**3.62  ±  0.532.71  ±  0.49**3.28  ±  0.736.9  ±  2.69.8  ±  1.710.4  ±  2.1
Chlorogenic acid504.21  ±  0.663.55  ±  0.443.73  ±  0.753.66  ±  0.593.56  ±  0.853.39  ±  0.768.1  ±  2.510.3  ±  1.710.8  ±  2.3
Rutin504.36  ±  0.803.40  ±  0.673.92  ±  0.543.29  ±  0.47*3.78  ±  0.922.83  ±  0.87*7.6  ±  2.09.3  ±  1.38.7  ±  1.9*
Combinationa503.48  ±  0.72*3.21  ±  0.58*3.40  ±  0.71*3.04  ±  0.55**2.84  ±  0.65**2.61  ±  0.77**7.2  ±  1.89.0  ±  1.9*8.2  ±  1.5*

Values are expressed as mean ± SD. N  =  10. *P  <  0.05, **P  <  0.01 compared with vehicle control. aThe ratio of rutin  :  chlorogenic acid  :  phaselic acid  :  salicylic acid in combination was 12 : 9 : 6 : 5, according to their contents in phenolic compounds-rich fraction from Urtica atrichocaulis (TFUA).

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