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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 908601, 12 pages
Research Article

Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness

1Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 180 Fenglin Road, Shanghai 200032, China
2Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

Received 12 October 2012; Accepted 12 November 2012

Academic Editor: Hui-Fen Liao

Copyright © 2012 Qing-An Jia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Qing-An Jia, Zhi-Ming Wang, Zheng-Gang Ren, Yang Bu, Xiao-Ying Xie, Yan-Hong Wang, Lan Zhang, Qiang-Bo Zhang, Tong-Chun Xue, Li-Fen Deng, and Zhao-You Tang, “Herbal compound "Songyou Yin" attenuates hepatoma cell invasiveness and met astasis through downregulation of cytokines secreted by activated hepatic s tellate cells,” Bmc Complementary and Alternative Medicine, vol. 13, 2013. View at Publisher · View at Google Scholar
  • Zhidong Wang, Jun Li, Yuanyuan Ji, Peng An, Shu Zhang, and Zongfang Li, “Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • Yang Bu, Qing-An Jia, Zheng-Gang Ren, Ju-Bo Zhang, Xue-Mei Jiang, Lei Liang, Tong-Chun Xue, Quan-Bao Zhang, Yan-Hong Wang, Lan Zhang, Xiao-Ying Xie, and Zhao-You Tang, “Maintenance of Stemness in Oxaliplatin-Resistant Hepatocellular Carcinoma Is Associated with Increased Autocrine of IGF1,” Plos One, vol. 9, no. 3, 2014. View at Publisher · View at Google Scholar
  • Yong Zhang, Qiang Zhang, Zhongze Fan, Jue Sun, Xulin Liu, Lingling Cheng, Ao Li, and Jianhua Xu, “A Chinese herbal Formula, Chang-Wei-Qin, Synergistically Enhances Antitumor Effect of Oxaliplatin,” Pathology & Oncology Research, vol. 21, no. 2, pp. 389–397, 2015. View at Publisher · View at Google Scholar
  • Yang Bu, Lun-Xiu Qin, Zhao-You Tang, Qing-An Jia, Zheng-Gang Ren, Tong-Chun Xue, Quan-Bao Zhang, Ke-Zhi Zhang, Qiang-Bo Zhang, Yang You, and Hui Tian, “The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells,” Oncotarget, vol. 6, no. 37, pp. 40068–40080, 2015. View at Publisher · View at Google Scholar
  • Quan-Bao Zhang, Xiang-Ting Meng, Yang Bu, Zheng-Gang Ren, Bo-Heng Zhang, Qing-An Jia, and Zhao-You Tang, “Herbal Compound Songyou Yin and Moderate Swimming Suppress Growth and Metastasis of Liver Cancer by Enhancing Immune Function,” Integrative Cancer Therapies, vol. 15, no. 3, pp. 368–375, 2016. View at Publisher · View at Google Scholar
  • Bijay Dhungel, Jason C. Steel, and Aparna Jayachandran, “Epithelial-to-mesenchymal plasticity of cancer stem cells: Therapeutic targets in hepatocellular carcinoma,” Journal of Hematology and Oncology, vol. 9, no. 1, 2016. View at Publisher · View at Google Scholar
  • Zhao-You Tang, Zheng-Gang Ren, Xiao-Dong Zhu, Cheng-Hao Wang, Cheng-Dong Qin, De-Ning Ma, Ying-Cong Wang, Bo-Gen Ye, Man-Qing Cao, and Dong-Mei Gao, “Astragaloside IV inhibits metastasis in hepatoma cells through the suppression of epithelial-mesenchymal transition via the Akt/GSK-3β/β-catenin pathway,” Oncology Reports, vol. 37, no. 3, pp. 1725–1735, 2017. View at Publisher · View at Google Scholar