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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 928643, 6 pages
http://dx.doi.org/10.1155/2012/928643
Research Article

Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

1Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China
2Institute of Changbai Mountain Natural Resources, Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China
3College of Pharmacy, Yanbian University, Yanji 133002, China

Received 17 September 2011; Revised 5 November 2011; Accepted 7 November 2011

Academic Editor: Mahmud Tareq Hassan Khan

Copyright © 2012 Chuanfeng Lv et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated. Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days. The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na+, K+-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.