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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 942384, 6 pages
Research Article

UPLC-QTOF/MS Analysis of Alkaloids in Traditional Processed Coptis chinensis Franch.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China

Received 16 August 2012; Revised 29 November 2012; Accepted 29 November 2012

Academic Editor: Muhammad Nabeel Ghayur

Copyright © 2012 Xue Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. State Pharmacopoeia Committee. Pharmacopoeia of People's Republic of China (2010 version), pp. 285, 2010.
  2. J. P. Kou, Y. Wu, Q. Z. Wang et al., “Studies on the sedative and hypnotic activities of JiaotaiWan prepared by raw or wine-processed Coptidis Rhizoma,” Pharmacology and Clinics of Chinese Materia Medica, vol. 23, no. 5, pp. 15–17, 2007. View at Google Scholar
  3. J. Jiang, X. B. Jia, X. H. Lu et al., “Empirical study of Fructus Evodiae processed Rhizoma Coptidis’s synergistic effect on breadboard gastric ulcer of rats,” China Jounral of Traditional Chinese Medicine and Pharmacy, vol. 25, no. 12, pp. 2130–2132, 2010. View at Google Scholar
  4. J. C. Li, X. L. Meng, R. Cui et al., “Comparison in pharmacodynamic effects of different types of processed Rhizoma Coptis on mouse diabetes,” Chinese Traditional Patent Medicine, vol. 32, no. 11, pp. 1922–1925.
  5. S. H. Zhou, W. J. Pan, X. H. Xiao et al., “Biothermokinetic studies on four properties of traditional Chinese materia medica-Comparison of different preparation properties of Coptidis Rhizoma by microcalorimetry,” Chinese Traditional and Herbal Drugs, vol. 35, no. 11, pp. 1230–1232, 2004. View at Google Scholar
  6. C. Yang, X. Qiu, and L. D. Kong, “Effects of different processing products of Rhizoma Coptidis on scavenging oxygen free radical and anti lipid peroxidation,” Journal of Nanjing University, vol. 37, no. 5, pp. 559–663, 2001. View at Google Scholar
  7. L. H. Liu and Z. L. Chen, “Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection,” Analytica Chimica Acta, vol. 737, pp. 99–104, 2012. View at Google Scholar
  8. F. Yang, T. Zhang, R. Zhang, and Y. Ito, “Application of analytical and preparative high-speed counter-current chromatography for separation of alkaloids from Coptis chinensis Franch,” Journal of Chromatography A, vol. 829, no. 1-2, pp. 137–141, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Yan, C. Jin, X. H. Xiao, and X. P. Dong, “Antimicrobial properties of berberines alkaloids in Coptis chinensis Franch by microcalorimetry,” Journal of Biochemical and Biophysical Methods, vol. 70, no. 6, pp. 845–849, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Giri and G. S. Kumar, “Self-structure induction in single stranded poly(A) by small molecules: studies on DNA intercalators, partial intercalators and groove binding molecules,” Archives of Biochemistry and Biophysics, vol. 474, no. 1, pp. 183–192, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. M. Islam and G. Suresh Kumar, “RNA targeting by small molecule alkaloids: studies on the binding of berberine and palmatine to polyribonucleotides and comparison to ethidium,” Journal of Molecular Structure, vol. 875, no. 1–3, pp. 382–391, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Chen, F. Wang, J. Liu, F. S. C. Lee, X. Wang, and H. Yang, “Analysis of alkaloids in Coptis chinensis Franch by accelerated solvent extraction combined with ultra performance liquid chromatographic analysis with photodiode array and tandem mass spectrometry detections,” Analytica Chimica Acta, vol. 613, no. 2, pp. 184–195, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Luo, B. Chen, and S. Yao, “Simultaneous analysis of protoberberine, indolequinoline and quinolone alkaloids in coptis-evodia herb couple and the Chinese herbal preparations by high-performance liquid chromatography-electrospray mass spectrometry,” Talanta, vol. 66, no. 1, pp. 103–110, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. Q. Liu, S. Qiu, H. Yu, Y. Ke, Y. Jin, and X. Liang, “Selective separation of structure-related alkaloids in Rhizoma Coptidis with “click” binaphthyl stationary phase and their structural elucidation with liquid chromatography-mass spectrometry,” Analyst, vol. 136, no. 20, pp. 4357–4365, 2011. View at Publisher · View at Google Scholar
  15. T. M. Hung, J. P. Lee, B. S. Min et al., “Magnoflorine from CoptidisRhizoma protects high density lipoprotein during oxidant stress,” Biological and Pharmaceutical Bulletin, vol. 30, no. 6, pp. 1157–1160, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Patra, C. T. Montgomery, A. J. Freyer et al., “The protoberberine alkaloids of Stephania suberosa,” Phytochemistry, vol. 26, no. 2, pp. 547–549, 1987. View at Google Scholar · View at Scopus
  17. Y. Li, G. Ren, Y. X. Wang et al., “Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes,” Journal of Translational Medicine, vol. 9, no. 62, pp. 1–10, 2011. View at Google Scholar
  18. L. Wang, X. Q. Zhang, Z. Q. Yin, Y. Wang, and W. C. Ye, “Two new amaryllidaceae alkaloids from the bulbs of Lycoris radiata,” Chemical and Pharmaceutical Bulletin, vol. 57, no. 6, pp. 610–611, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Hanaoka, T. Motonishi, and C. Mukai, “Chemical transformation of protoberberines. Part 9. A biomimetic synthesis of oxychelerythrine, dihydrochelerythrine, and chelerythrine from berberine,” Journal of the Chemical Society, Perkin Transactions 1, pp. 2253–2256, 1986. View at Google Scholar · View at Scopus
  20. Y. H. Kuang, J. J. Zhu, Z. M. Wang, and Q. W. Zhang, “Simultaneous quantitative analysis of five alkaloids in rhizoma of Coptis chinensis by multi-components assay by single marker,” Chinese Pharmaceutical Journal, vol. 44, no. 5, pp. 390–394, 2009. View at Google Scholar · View at Scopus
  21. H. A. Jung, B. S. Min, T. Yokozawa, J. H. Lee, Y. S. Kim, and J. S. Choi, “Anti-Alzheimer and antioxidant activities of CoptidisRhizoma alkaloids,” Biological and Pharmaceutical Bulletin, vol. 32, no. 8, pp. 1433–1438, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Rueffer and M. H. Zenk, “Columbamine, the central intermediate in the late stages of protoberberine biosynthesis,” Tetrahedron Letters, vol. 27, no. 8, pp. 923–924, 1986. View at Google Scholar · View at Scopus
  23. J. Vrba, P. Doležel, J. Vičar, M. Modrianský, and J. Ulrichová, “Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells,” Toxicology in Vitro, vol. 22, no. 4, pp. 1008–1017, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Y. Yao, Z. M. Zhou, X. L. Li et al., “Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus),” Veterinary Parasitology, vol. 183, no. 1-2, pp. 8–13, 2011. View at Google Scholar