Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 262796, 13 pages
http://dx.doi.org/10.1155/2013/262796
Research Article

The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing

Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

Received 28 November 2012; Accepted 8 May 2013

Academic Editor: Taiping Fan

Copyright © 2013 Shu-Yi Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [24 citations]

The following is the list of published articles that have cited the current article.

  • Chibo Liu, Lihui Yin, Jiaqi Chen, and Jiayu Chen, “The apoptotic effect of shikonin on human papillary thyroid carcinoma cells through mitochondrial pathway,” Tumor Biology, vol. 35, no. 3, pp. 1791–1798, 2014. View at Publisher · View at Google Scholar
  • Yuanyuan Xu, Xuegang Xu, Xinghua Gao, Hongduo Chen, and Long Geng, “Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway,” International Immunopharmacology, 2014. View at Publisher · View at Google Scholar
  • Jale Aliasl, Fariba Khoshzaban, Behrooz Barikbin, Mohsen Naseri, Mohammad Kamalinejad, Fateme Emadi, Zahra Razzaghi, Daryush Talei, Maryam Yousefi, Fateme Aliasl, Maryam Barati, Parvaneh Mohseni Moghaddam, Seyyed Abbas Hasheminejad, and Hossein Esmailzad Nami, “Comparing the Healing Effects of Arnebia euchroma Ointment with Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial,” Iranian Red Crescent Medical Journal, vol. 16, no. 10, 2014. View at Publisher · View at Google Scholar
  • Dapeng Zhao, Kailong Yuan, Yanmeng Xiao, Chenxu Wang, Wei Yang, Yanqin Yang, Guojun Zhou, Yu Wang, and Jingwei Xu, “Two new dimeric naphthoquinones with neuraminidase inhibitory activity from Lithospermum erythrorhizon,” Natural Product Research, vol. 29, no. 10, pp. 908–913, 2014. View at Publisher · View at Google Scholar
  • Shu-Yi Yin, M. S. Pradeep, and Ning-Sun Yang, “Use of Omics Approaches for Developing Immune-Modulatory and Anti-Inflammatory Phytomedicines,” Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods, pp. 453–475, 2015. View at Publisher · View at Google Scholar
  • Yan Yan, Minao Furumura, Takako Gouya, Atsufumi Iwanaga, Kwesi Teye, Sanae Numata, Tadashi Karashima, Xiao-Guang Li, and Takashi Hashimoto, “Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-kappa B Translocation via Proteasome Inhibition In Vitro,” Chinese Medical Journal, vol. 128, no. 16, pp. 2228–2233, 2015. View at Publisher · View at Google Scholar
  • Xiaoyang Ma, Jia Chen, Bei Xu, Xiao Long, Han Qin, Robert Chunhua Zhao, and Xiaojun Wang, “Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro,” International Journal Of Molecular Medicine, vol. 35, no. 5, pp. 1246–1256, 2015. View at Publisher · View at Google Scholar
  • Ching-Wen Lou, Chiung-Yun Chang, Zong-Han Wu, and Jia-Horng Lin, “The optimal extracting process, manufacturing technique and biological evaluation of Lithospermum erythrorhizon microcapsules,” Materials Science & Engineering C-Materials For Biological Applications, vol. 48, pp. 165–171, 2015. View at Publisher · View at Google Scholar
  • Xuemin Zhang, Wenyu Hu, Fang Wu, Xue Yuan, and Jian Hu, “Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells,” Canadian Journal of Physiology and Pharmacology, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Jale Aliasl, Behrooz Barikbin, Fariba Khoshzaban, Mohsen Naseri, Reza Sedaghat, Mohammad Kamalinejad, Daryush Talei, Fatemeh Emadi, Zahra Akbari, Fatemeh Aliasl, Niloofar Y. Jalaly, and Parvaneh Mohseni-Moghaddam, “Effect of Arnebia euchroma ointment on post-laser wound healing in rats,” Journal Of Cosmetic And Laser Therapy, vol. 17, no. 1, pp. 41–45, 2015. View at Publisher · View at Google Scholar
  • Jian Huang, Changhong Zhu, Xian Zhao, Haihua Yuan, Ming Xu, Qin Chen, Bin Jiang, Jianxiu Yu, Cheng Chen, Hailong Zhang, Rong Deng, Jinzhuo Dou, and Yanli Wang, “Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors,” Oncotarget, vol. 6, no. 2, pp. 979–994, 2015. View at Publisher · View at Google Scholar
  • Sha Zhao, Xiang-Fei Lin, Xiao-Fang Zhu, Min Pan, Fei-Fei Chen, and Yan-Ru Liu, “Effects of Shikonin on Th17 related cytokines in psoriasis-like mouse model,” Journal of Clinical Dermatology, vol. 45, no. 5, pp. 323–327, 2016. View at Publisher · View at Google Scholar
  • Shu-Yi Yin, Thomas Efferth, Feng-Yin Jian, Chia-I. Liu, Andrew H.J. Wang, Pei-Wen Hsiao, Ning-Sun Yang, Yung-Hsiang Chen, and Yet-Ran Chen, “Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1,” Oncotarget, vol. 7, no. 28, pp. 43629–43653, 2016. View at Publisher · View at Google Scholar
  • Eun-Kyung Kim, Eun-Ju Choi, and Trishna Debnath, “Role of phytochemicals in the inhibition of epithelial–mesenchymal transition in cancer metastasis,” Food Funct., 2016. View at Publisher · View at Google Scholar
  • Jun Yang, Zhao Wang, and Dong-Lin Chen, “Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress,” Biomedicine & Pharmacotherapy, vol. 93, pp. 1343–1357, 2017. View at Publisher · View at Google Scholar
  • Eerik Aunin, David Broadley, Mohammed I. Ahmed, Andrei N. Mardaryev, and Natalia V. Botchkareva, “Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing:Involvement of miR-200c in wound repair,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Yei-San Hsieh, Chiung-Ho Liao, Wan-Shen Chen, Jih-Tung Pai, and Meng-Shih Weng, “Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Jeong-Hae Choi, Hae-June Lee, Gyoo-Cheon Kim, Yeon-Suk Song, and Jin-Woo Hong, “The topical application of low-temperature argon plasma enhances the anti-inflammatory effect of Jaun-ointment on DNCB-induced NC/Nga mice,” BMC Complementary and Alternative Medicine, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Shu-Yi Yin, Ning-Sun Yang, and Tien-Jen Lin, “Phytochemicals Approach for Developing Cancer Immunotherapeutics,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Ali Mohammadi, Behzad Mansoori, and Behzad Baradaran, “Regulation of miRNAs by herbal medicine: An emerging field in cancer therapies,” Biomedicine & Pharmacotherapy, vol. 86, pp. 262–270, 2017. View at Publisher · View at Google Scholar
  • Weirong Xiao, Hua Tang, Meng Wu, Yangying Liao, Ke Li, Lan Li, and Xiaopeng Xu, “Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway.,” Bioscience reports, vol. 37, no. 6, 2017. View at Publisher · View at Google Scholar
  • Bao-Ying Fei, Xujun He, Jie Ma, Mei Zhang, and Rui Chai, “FoxM1 is associated with metastasis in colorectal cancer through induction of the epithelial-mesenchymal transition.,” Oncology letters, vol. 14, no. 6, pp. 6553–6561, 2017. View at Publisher · View at Google Scholar
  • In Gyu Kim, Uhee Jung, Kyoung Ah Kang, Jeong Eon Park, Yu Jae Hyun, Kristina Shilnikova, Ao Xuan Zhen, Yong Joo Jeong, Jin Won Hyun, Mei Jing Piao, and Yea Seong Ryu, “Shikonin induces mitochondria-mediated apoptosis and attenuates epithelial-mesenchymal transition in cisplatin-resistant human ovarian cancer cells,” Oncology Letters, vol. 15, no. 4, pp. 5417–5424, 2018. View at Publisher · View at Google Scholar
  • Chun-Hsu Yao, Kuo-Yu Chen, Yueh-Sheng Chen, Shu-Jing Li, and Chiung-Hua Huang, “Lithospermi radix extract-containing bilayer nanofiber scaffold for promoting wound healing in a rat model,” Materials Science and Engineering: C, 2018. View at Publisher · View at Google Scholar