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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 262796, 13 pages
Research Article

The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing

Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

Received 28 November 2012; Accepted 8 May 2013

Academic Editor: Taiping Fan

Copyright © 2013 Shu-Yi Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Chibo Liu, Lihui Yin, Jiaqi Chen, and Jiayu Chen, “The apoptotic effect of shikonin on human papillary thyroid carcinoma cells through mitochondrial pathway,” Tumor Biology, vol. 35, no. 3, pp. 1791–1798, 2014. View at Publisher · View at Google Scholar
  • Yuanyuan Xu, Xuegang Xu, Xinghua Gao, Hongduo Chen, and Long Geng, “Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway,” International Immunopharmacology, 2014. View at Publisher · View at Google Scholar
  • Jale Aliasl, Fariba Khoshzaban, Behrooz Barikbin, Mohsen Naseri, Mohammad Kamalinejad, Fateme Emadi, Zahra Razzaghi, Daryush Talei, Maryam Yousefi, Fateme Aliasl, Maryam Barati, Parvaneh Mohseni Moghaddam, Seyyed Abbas Hasheminejad, and Hossein Esmailzad Nami, “Comparing the Healing Effects of Arnebia euchroma Ointment with Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial,” Iranian Red Crescent Medical Journal, vol. 16, no. 10, 2014. View at Publisher · View at Google Scholar
  • Yan Yan, Minao Furumura, Takako Gouya, Atsufumi Iwanaga, Kwesi Teye, Sanae Numata, Tadashi Karashima, Xiao-Guang Li, and Takashi Hashimoto, “Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-kappa B Translocation via Proteasome Inhibition In Vitro,” Chinese Medical Journal, vol. 128, no. 16, pp. 2228–2233, 2015. View at Publisher · View at Google Scholar
  • Xiaoyang Ma, Jia Chen, Bei Xu, Xiao Long, Han Qin, Robert Chunhua Zhao, and Xiaojun Wang, “Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro,” International Journal Of Molecular Medicine, vol. 35, no. 5, pp. 1246–1256, 2015. View at Publisher · View at Google Scholar
  • Ching-Wen Lou, Chiung-Yun Chang, Zong-Han Wu, and Jia-Horng Lin, “The optimal extracting process, manufacturing technique and biological evaluation of Lithospermum erythrorhizon microcapsules,” Materials Science & Engineering C-Materials For Biological Applications, vol. 48, pp. 165–171, 2015. View at Publisher · View at Google Scholar
  • Xuemin Zhang, Wenyu Hu, Fang Wu, Xue Yuan, and Jian Hu, “Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells,” Canadian Journal of Physiology and Pharmacology, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Jale Aliasl, Behrooz Barikbin, Fariba Khoshzaban, Mohsen Naseri, Reza Sedaghat, Mohammad Kamalinejad, Daryush Talei, Fatemeh Emadi, Zahra Akbari, Fatemeh Aliasl, Niloofar Y. Jalaly, and Parvaneh Mohseni-Moghaddam, “Effect of Arnebia euchroma ointment on post-laser wound healing in rats,” Journal Of Cosmetic And Laser Therapy, vol. 17, no. 1, pp. 41–45, 2015. View at Publisher · View at Google Scholar