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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 262796, 13 pages
http://dx.doi.org/10.1155/2013/262796
Research Article

The Phytochemical Shikonin Stimulates Epithelial-Mesenchymal Transition (EMT) in Skin Wound Healing

Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

Received 28 November 2012; Accepted 8 May 2013

Academic Editor: Taiping Fan

Copyright © 2013 Shu-Yi Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • Chibo Liu, Lihui Yin, Jiaqi Chen, and Jiayu Chen, “The apoptotic effect of shikonin on human papillary thyroid carcinoma cells through mitochondrial pathway,” Tumor Biology, vol. 35, no. 3, pp. 1791–1798, 2014. View at Publisher · View at Google Scholar
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  • Yan Yan, Minao Furumura, Takako Gouya, Atsufumi Iwanaga, Kwesi Teye, Sanae Numata, Tadashi Karashima, Xiao-Guang Li, and Takashi Hashimoto, “Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-kappa B Translocation via Proteasome Inhibition In Vitro,” Chinese Medical Journal, vol. 128, no. 16, pp. 2228–2233, 2015. View at Publisher · View at Google Scholar
  • Xiaoyang Ma, Jia Chen, Bei Xu, Xiao Long, Han Qin, Robert Chunhua Zhao, and Xiaojun Wang, “Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro,” International Journal Of Molecular Medicine, vol. 35, no. 5, pp. 1246–1256, 2015. View at Publisher · View at Google Scholar
  • Ching-Wen Lou, Chiung-Yun Chang, Zong-Han Wu, and Jia-Horng Lin, “The optimal extracting process, manufacturing technique and biological evaluation of Lithospermum erythrorhizon microcapsules,” Materials Science & Engineering C-Materials For Biological Applications, vol. 48, pp. 165–171, 2015. View at Publisher · View at Google Scholar
  • Xuemin Zhang, Wenyu Hu, Fang Wu, Xue Yuan, and Jian Hu, “Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells,” Canadian Journal of Physiology and Pharmacology, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Jale Aliasl, Behrooz Barikbin, Fariba Khoshzaban, Mohsen Naseri, Reza Sedaghat, Mohammad Kamalinejad, Daryush Talei, Fatemeh Emadi, Zahra Akbari, Fatemeh Aliasl, Niloofar Y. Jalaly, and Parvaneh Mohseni-Moghaddam, “Effect of Arnebia euchroma ointment on post-laser wound healing in rats,” Journal Of Cosmetic And Laser Therapy, vol. 17, no. 1, pp. 41–45, 2015. View at Publisher · View at Google Scholar
  • Sha Zhao, Xiang-Fei Lin, Xiao-Fang Zhu, Min Pan, Fei-Fei Chen, and Yan-Ru Liu, “Effects of Shikonin on Th17 related cytokines in psoriasis-like mouse model,” Journal of Clinical Dermatology, vol. 45, no. 5, pp. 323–327, 2016. View at Publisher · View at Google Scholar
  • Shu-Yi Yin, Thomas Efferth, Feng-Yin Jian, Chia-I. Liu, Andrew H.J. Wang, Pei-Wen Hsiao, Ning-Sun Yang, Yung-Hsiang Chen, and Yet-Ran Chen, “Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1,” Oncotarget, vol. 7, no. 28, pp. 43629–43653, 2016. View at Publisher · View at Google Scholar
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  • Jun Yang, Zhao Wang, and Dong-Lin Chen, “Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress,” Biomedicine & Pharmacotherapy, vol. 93, pp. 1343–1357, 2017. View at Publisher · View at Google Scholar
  • Yei-San Hsieh, Chiung-Ho Liao, Wan-Shen Chen, Jih-Tung Pai, and Meng-Shih Weng, “Shikonin Inhibited Migration and Invasion of Human Lung Cancer Cells via Suppression of c-Met-Mediated Epithelial-to-Mesenchymal Transition,” Journal of Cellular Biochemistry, 2017. View at Publisher · View at Google Scholar
  • Shu-Yi Yin, Ning-Sun Yang, and Tien-Jen Lin, “Phytochemicals Approach for Developing Cancer Immunotherapeutics,” Frontiers in Pharmacology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Eerik Aunin, David Broadley, Mohammed I. Ahmed, Andrei N. Mardaryev, and Natalia V. Botchkareva, “Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing:Involvement of miR-200c in wound repair,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Ali Mohammadi, Behzad Mansoori, and Behzad Baradaran, “Regulation of miRNAs by herbal medicine: An emerging field in cancer therapies,” Biomedicine & Pharmacotherapy, vol. 86, pp. 262–270, 2017. View at Publisher · View at Google Scholar