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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 350519, 13 pages
http://dx.doi.org/10.1155/2013/350519
Research Article

Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response

1Department of Human Pharmacology and Toxicology, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, 612 42 Brno, Czech Republic
2Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 3, 625 00 Brno, Czech Republic
3Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, 612 42 Brno, Czech Republic
4Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Královopolská 135, 612 65 Brno, Czech Republic
5International Clinical Research Center, St. Anne’s University Hospital, Pekařská 53, 656 91 Brno, Czech Republic
6Nature Conservation Center, American University of Beirut, P.O. Box 11-0236, Beirut 1107 2020, Lebanon
7Department of Biology, Faculty of Arts and Sciences, American University of Beirut, P.O. Box 11-0236, Beirut 1107 2020, Lebanon

Received 26 March 2013; Accepted 26 April 2013

Academic Editor: Thomas Efferth

Copyright © 2013 Peter Kollar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Cisplatin, strong inducer of apoptosis, is commonly used chemotherapy drug. In our experimental settings, we included cisplatin as a model compound to compare its effects on apoptosis with those of MA flavonoids. As shown in Supplementary Figure 1, 24 h treatment with cisplatin caused in THP-1 cells significant changes in G1 sub-peak accumulation and in both apoptotic markers (cleaved PARP and caspase 3).

  1. Supplementary Material