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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 548498, 12 pages
http://dx.doi.org/10.1155/2013/548498
Research Article

A Systems Biology-Based Investigation into the Pharmacological Mechanisms of Wu Tou Tang Acting on Rheumatoid Arthritis by Integrating Network Analysis

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China

Received 11 January 2013; Accepted 20 February 2013

Academic Editor: Aiping Lu

Copyright © 2013 Yanqiong Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Ming Yang, Jia-Lei Chen, Li-Wen Xu, and Guang Ji, “Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Yanqiong Zhang, Xiaodong Guo, Danhua Wang, Ruisheng Li, Xiaojuan Li, Ying Xu, Zhenli Liu, Zhiqian Song, Ya Lin, Zhiyan Li, and Na Lin, “A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma,” Scientific Reports, vol. 4, 2014. View at Publisher · View at Google Scholar
  • M-M Zhang, Y-S Jiang, H-C Lv, H-B Mu, J. Li, Z-W Shang, and R-J Zhang, “Pathway-based association analysis of two genome-wide screening data identifies rheumatoid arthritis-related pathways,” Genes and Immunity, vol. 15, no. 7, pp. 487–494, 2014. View at Publisher · View at Google Scholar
  • Yao Qi, Shizhe Li, Zifeng Pi, Fengrui Song, Na Lin, and Zhiqiang Liu, “Chemical profiling of Wu-tou decoction by UPLC-Q-TOF-MS,” Talanta, vol. 118, pp. 21–29, 2014. View at Publisher · View at Google Scholar
  • Yanqiong Zhang, Ming Bai, Bo Zhang, Chunfang Liu, Qiuyan Guo, Yanqun Sun, Danhua Wang, Chao Wang, Yini Jiang, Na Lin, and Shao Li, “Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network a,” Scientific Reports, vol. 5, 2015. View at Publisher · View at Google Scholar
  • Qiuyan Guo, Micun Zhong, Xia Mao, Haiyu Xu, Yanqiong Zhang, and Na Lin, “A systems biology perspective on the molecular mechanisms underlying the therapeutic effects of Buyang Huanwu Decoction on ischemic stroke,” Rejuvenation Research, pp. 150216224023005, 2015. View at Publisher · View at Google Scholar
  • Lin Huang, Qi Lv, Duoli Xie, Tieliu Shi, and Chengping Wen, “Deciphering the Potential Pharmaceutical Mechanism of Chinese Traditional Medicine (Gui-Zhi-Shao-Yao-Zhi-Mu) on Rheumatoid Arthritis,” Scientific Reports, vol. 6, pp. 22602, 2016. View at Publisher · View at Google Scholar
  • Ya-Fei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Yong-Hong Hu, and Sheng-Hao Tu, “Effects of Wutou Decoction on DNA Methylation and Histone Modifications in Rats with Collagen-Induced Arthritis,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Xu Haiyu, Shi Yang, Zhang Yanqiong, Jia Qiang, Li Defeng, Zhang Yi, Liu Feng, and Yang Hongjun, “Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative phar,” Molecular Biosystems, vol. 12, no. 1, pp. 233–245, 2016. View at Publisher · View at Google Scholar