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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 698190, 1 page

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

1Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
2Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
3Graduate Institute of Applied Living Science, Tainan University of Technology, Tainan City 710, Taiwan
4Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077
5Tissue Culture Center, New York Eye and Ear Infirmary, New York Medical College, New York, NY 10009, USA

Received 5 December 2013; Accepted 5 December 2013

Copyright © 2013 Shun-Fa Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Natural bioactives or phytochemicals are generally referred to as the compounds that have specific biological activity in human. Studies have shown that natural phytochemicals derived from certain plants have the capability to prevent carcinogenesis. In this special issue, we collected numerous studies which provide novel evidence to support the opinion. For instance, [6]-gingerol prevents disassembly of cell junctions and activities of MMPs in invasive human pancreas cancer cells; butein inhibits angiogenesis of human endothelial progenitor cells; the anticancer effects of sterol fraction come from red algae porphyra dentata; zeaxanthin induces apoptosis in human uveal melanoma cells; and ocotillol enhanced the antitumor activity of doxorubicin. It is therefore believed that the appropriate application of natural bioactives or phytochemicals should be a supplementary and safe way to prevent carcinogenesis and/or to enhance the efficacy of cancer therapy.

Shun-Fa  Yang
Chia-Jui  Weng
Gautam  Sethi
Dan-Ning  Hu