Fenugreek Prevents the Development of STZ-Induced Diabetic Nephropathy in a Rat Model of Diabetes
Figure 5
Fenugreek inhibited mRNA and protein expressions of CTGF. Tests and calculations for mRNA and protein levels of CTGF were same with TGF-β1 in Figure 4. Upregulated mRNA and protein expressions of CTGF were found in diabetic kidney of DN group compared with Con group; then they were downregulated by fenugreek treatment in DF group (a and b). At last, the results were further confirmed by the immunohistochemistry test (c). versus Con; versus DN.