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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 478290, 9 pages
http://dx.doi.org/10.1155/2014/478290
Research Article

Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil

1Laboratório de Farmacologia e Imunidade (LaFI), Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, 57072-970 Maceió, AL, Brazil
2Laboratório de Pesquisa em Recursos Naturais, Universidade Federal de Alagoas, Maceió, AL, Brazil
3Laboratório de Plantas Tropicais (LPT), PPG-Dibict, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brazil

Received 10 April 2014; Revised 7 June 2014; Accepted 23 June 2014; Published 13 July 2014

Academic Editor: Ulysses Paulino Albuquerque

Copyright © 2014 Aline Cavalcanti De Queiroz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Cuervo, G. B. Domont, and J. B. De Jesus, “Proteomics of trypanosomatids of human medical importance,” Journal of Proteomics, vol. 73, no. 5, pp. 845–867, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. V. S. Amato, F. F. Tuon, H. A. Bacha, V. A. Neto, and A. C. Nicodemo, “Mucosal leishmaniasis. Current scenario and prospects for treatment,” Acta Tropica, vol. 105, no. 1, pp. 1–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. C. S. Peacock, K. Seeger, D. Harris et al., “Comparative genomic analysis of three Leishmania species that cause diverse human disease,” Nature Genetics, vol. 39, no. 7, pp. 839–847, 2007. View at Publisher · View at Google Scholar
  4. J. Alvar, I. D. Vélez, C. Bern et al., “Leishmaniasis worldwide and global estimates of its incidence,” PLoS ONE, vol. 7, no. 5, Article ID e35671, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. M. C. C. Malta, H. P. Tinoco, M. N. Xavier, A. L. S. Vieira, É. A. Costa, and R. L. Santos, “Naturally acquired visceral leishmaniasis in non-human primates in Brazil,” Veterinary Parasitology, vol. 169, no. 1-2, pp. 193–197, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Ouakad, N. Bahi-Jaber, M. Chenik, K. Dellagi, and H. Louzir, “Selection of endogenous reference genes for gene expression analysis in Leishmania major developmental stages,” Parasitology Research, vol. 101, no. 2, pp. 473–477, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Baptista, A. O. Schubach, M. F. Madeira et al., “Leishmania (Viannia) braziliensis genotypes identified in lesions of patients with atypical or typical manifestations of tegumentary leishmaniasis: evaluation by two molecular markers,” Experimental Parasitology, vol. 121, no. 4, pp. 317–322, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. E. H. Gomes Rodrigues, M. E. Felinto de Brito, M. G. Mendonça et al., “Evaluation of PCR for diagnosis of American cutaneous leishmaniasis in an area of endemicity in Northeastern Brazil,” Journal of Clinical Microbiology, vol. 40, no. 10, pp. 3572–3576, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. A. C. T. Da Silva, E. Cupolillo, Â. C. Volpini, R. Almeida, and G. A. S. Romero, “Species diversity causing human cutaneous leishmaniasis in Rio Branco, state of Acre, Brazil,” Tropical Medicine and International Health, vol. 11, no. 9, pp. 1388–1398, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Chai, S. Yan, I. L. K. Wong, L. M. C. Chow, and H. Sun, “Complexation of antimony (SbV) with guanosine 5′-monophosphate and guanosine 5′-diphospho-D-mannose: formation of both mono- and bis-adducts,” Journal of Inorganic Biochemistry, vol. 99, no. 12, pp. 2257–2263, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. E. T. Borborema, H. F. D. A. Junior, J. A. O. Junior, and N. do Nascimento, “In vitro antileishmanial properties of neutron-irradiated meglumine antimoniate,” Brazilian Archives of Biology and Technology, vol. 48, no. 2, pp. 63–68, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Ouellette, J. Drummelsmith, and B. Papadopoulou, “Leishmaniasis: drugs in the clinic, resistance and new developments,” Drug Resistance Updates, vol. 7, no. 4-5, pp. 257–266, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. K. K. Pitzer, K. A. Werbovetz, J. J. Brendle, and J. P. Scovill, “Synthesis and biological evaluation of 4-chloro-3, 5-dinitrobenzotrifluoride analogues as antileishmanial agents,” Jornal of Medicinal Chemistry, vol. 41, no. 24, pp. 4885–4889, 1998. View at Google Scholar
  14. A. Dutta, G. Mandal, C. Mandal, and M. Chatterjee, “In vitro antileishmanial activity of Aloe vera leaf exudate: a potential herbal therapy in leishmaniasis,” Glycoconjugate Journal, vol. 24, no. 1, pp. 81–86, 2007. View at Publisher · View at Google Scholar
  15. M. J. Chan-Bacab and L. M. Peña-Rodriguez, “Plant natural products with leishamanicidal activity,” Natural Product Report, vol. 18, no. 6, pp. 674–688, 2001. View at Google Scholar
  16. A. C. Queroz, Levantamento Etnofarmacológico de Plantas Medicinais Utilizadas no Tratamento de Leishmaniose Tegumentar em Novo Lino, Colônia Leopoldina e União dos Palmares, AL. Relatório de Iniciação Científica. CNPq, Universidade Federal de Alagoas, 2008.
  17. U. P. de Albuquerque, V. A. da Silva, M. D. C. Cabral, N. Leal Alencar, and L. D. H. C. Andrade, “Comparisons between the use of medicinal plants in indigenous and rural caatinga (dryland) communities in NE Brazil,” Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol. 7, no. 3, pp. 157–170, 2008. View at Google Scholar · View at Scopus
  18. R. F. Hussain, A. M. Nouri, and R. T. Oliver, “A new approach for measurement of cytotoxicity using colorimetric assay,” Journal of Immunological Methods, vol. 160, no. 1, pp. 89–96, 1993. View at Publisher · View at Google Scholar
  19. N. A. Gomes, C. R. Gattass, V. Barreto-De-Souza, M. E. Wilson, and G. A. Dos Reis, “TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar,” The Journal of Immunology, vol. 164, no. 4, pp. 2001–2008, 2000. View at Publisher · View at Google Scholar
  20. C. M. D. C. Gomes, H. Goto, V. L. Ribeiro da Matta, M. D. Laurenti, M. Gidlund, and C. E. P. Corbett, “Insulin-like growth factor (IGF)-I affects parasite growth and host cell migration in experimental cutaneous leishmaniasis,” International Journal of Experimental Pathology, vol. 81, no. 4, pp. 249–255, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. F. L. Ribeiro-Gomes, A. C. Otero, N. A. Gomes et al., “Macrophage interactions with neutrophils regulate leishmania major infection,” Journal of Immunology, vol. 172, no. 7, pp. 4454–4462, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. M. P. Nunes, L. Cysne-Finkelstein, B. C. Monteiro, D. M. de Souza, N. A. Gomes, and G. A. DosReis, “CD40 signaling induces reciprocal outcomes in Leishmania-infected macrophages; roles of host genotype and cytokine milieu,” Microbes and Infection, vol. 7, no. 1, pp. 78–85, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Dutta, D. Sarkar, A. Gurib-Fakim, C. Mandal, and M. Chatterjee, “In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis,” Parasitology Research, vol. 102, no. 6, pp. 1235–1242, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Monzote, A. M. Montalvo, R. Scull, M. Miranda, and J. Abreu, “Activity, toxicity and analysis of resistance of essential oil from Chenopodium ambrosioides after intraperitoneal, oral and intralesional administration in BALB/c mice infected with Leishmania amazonensis: a preliminary study,” Biomedicine & Pharmacotherapy, vol. 61, no. 2-3, pp. 148–153, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. M. F. Arrigoni-Blank, A. R. Antoniolli, L. C. Caetano, D. A. Campos, A. F. Blank, and P. B. Alves, “Antinociceptive activity of the volatile oils of Hyptis pectinata L. Poit. (Lamiaceae) genotypes,” Phytomedicine, vol. 15, no. 5, pp. 334–339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. P. O. Santos, M. D. J. C. Costa, J. A. B. Alves et al., “Chemical composition and antimicrobial activity of the essential oil of Hyptis pectinata (L.) Poit.,” Quimica Nova, vol. 31, no. 7, pp. 1648–1652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. M. D. Bispo, R. H. V. Mourão, E. M. Franzotti et al., “Antinociceptive and antiedematogenic effects of the aqueous extract of Hyptis pectinata leaves in experimental animals,” Journal of Ethnopharmacology, vol. 76, no. 1, pp. 81–86, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. D. M. Boalino, J. D. Connolly, S. McLean, W. F. Reynolds, and W. F. Tinto, “α-Pyrones and a 2(5H)-furanone from Hyptis pectinata,” Phytochemistry, vol. 64, no. 7, pp. 1303–1307, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Carmona, J. Sáez, H. Granados et al., “Antiprotozoal 6-substituted-5,6-dihydro-α-pyrones from Raimondia cf. Monoica,” Natural Product Research, vol. 17, no. 4, pp. 275–280, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Kayser, A. F. Kiderlen, and S. L. Croft, “Antileishmanial activity of two γ-pyrones from Podolepsis hieracioides (Asteraceae),” Acta Tropica, vol. 86, no. 1, pp. 105–107, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. R. A. Falcao, P. L. A. do Nascimento, S. A. de Souza et al., “Antileishmanial phenylpropanoids from the leaves of Hyptis pectinata (L.) poit,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 460613, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Dutta, S. Bandyopadhyay, C. Mandal, and M. Chatterjee, “Aloe vera leaf exudate induces a caspase-independent cell death in Leishmania donovani promastigotes,” Journal of Medical Microbiology, vol. 56, no. 5, pp. 629–636, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. S. K. Raghav, B. Gupta, A. Shrivastava, and H. R. Das, “Inhibition of lipopolysaccharide-inducible nitric oxide synthase and IL-1β through suppression of NF-κB activation by 3-(1′-1′-dimethyl-allyl)-6-hydroxy-7-methoxy-coumarin isolated from Ruta graveolens L.,” European Journal of Pharmacology, vol. 560, no. 1, pp. 69–80, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. K. M. Ahua, J. R. Ioset, A. Ransijn, J. Mauël, S. Mavi, and K. Hostettmann, “Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica,” Phytochemistry, vol. 65, no. 7, pp. 963–968, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. F. G. Braga, M. L. M. Bouzada, R. L. Fabri et al., “Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 396–402, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. M. A. Brenzan, C. V. Nakamura, B. Prado Dias Filho, T. Ueda-Nakamura, M. C. M. Young, and D. Aparício Garcia Cortez, “Antileishmanial activity of crude extract and coumarin from Calophyllum brasiliense leaves against Leishmania amazonensis,” Parasitology Research, vol. 101, no. 3, pp. 715–722, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. M. A. Brenzan, I. C. Piloto Ferreira, M. V. Campana Lonardoni et al., “Activity of extracts and coumarins from the leaves of Calophyllum brasiliense on Leishmania braziliensis,” Pharmaceutical Biology, vol. 46, no. 6, pp. 380–386, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. A. G. Neto, A. A. da Silva Filho, J. M. L. C. Costa et al., “Evaluation of the trypanocidal and leishmanicidal in vitro activity of the crude hydroalcoholic extract of Pfaffia glomerata (Amarathanceae) roots,” Phytomedicine, vol. 11, no. 7-8, pp. 662–665, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. C. S. Freitas, C. H. Baggio, J. E. da Silva-Santos et al., “Involvement of nitric oxide in the gastroprotective effects of an aqueous extract of Pfaffia glomerata (Spreng) Pedersen, Amaranthaceae, in rats,” Life Sciences, vol. 74, no. 9, pp. 1167–1179, 2004. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Franca, E. L. Lago, and P. D. Marsden, “Plants used in the treatment of leishmanial ulcers due to Leishmania (Viannia) braziliensis in an endemic area of Bahia, Brazil,” Revista da Sociedade Brasileira de Medicina Tropical, vol. 29, no. 3, pp. 229–232, 1996. View at Publisher · View at Google Scholar · View at Scopus
  41. J. L. Bezerra, G. C. Costa, T. C. Lopes et al., “Avaliação da atividade leishmanicida in vitro de plantas medicinais,” Revista Brasileira de Farmacognosia, vol. 16, pp. 631–637, 2006. View at Publisher · View at Google Scholar
  42. L. Monzote, A. M. Montalvo, S. Almanonni, R. Scull, M. Miranda, and J. Abreu, “Activity of the essential oil from Chenopodium ambrosioides grown in Cuba against Leishmania amazonensis,” Chemotherapy, vol. 52, no. 3, pp. 130–136, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. L. Monzote, A. M. Montalvo, R. Scull, M. Miranda, and J. Abreu, “Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis,” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 49, no. 4, pp. 257–260, 2007. View at Google Scholar · View at Scopus
  44. F. J. Patrício, G. C. Costa, P. V. S. Pereira et al., “Efficacy of the intralesional treatment with Chenopodium ambrosioides in the murine infection by Leishmania amazonensis,” Journal of Ethnopharmacology, vol. 115, no. 2, pp. 313–319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. G. V. B. Cruz, P. V. S. Pereira, F. J. Patrício et al., “Increase of cellular recruitment, phagocytosis ability and nitric oxide production induced by hydroalcoholic extract from Chenopodium ambrosioides leaves,” Journal of Ethnopharmacology, vol. 111, no. 1, pp. 148–154, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. B. A. L. de Freitas, D. M. de Oliveira, D. G. de Oliveira, and L. J. Gomes, “Conhecimento e uso da flora pelos moradores do Assentamento São Judas Tadeu, Porto Da Folha, Sergipe,” Revista Ouricuri, vol. 3, no. 2, pp. 19–36, 2013. View at Google Scholar
  47. V. H. M. de Lima, J. P. Gomes-Neto, and M. D. S. Cavalcanti, “Recursos vegetais utilizados pela comunidade de Vila Velha, Ilha de Itamaracá, Pernambuco, Brasil,” Revista Ouricuri, vol. 3, no. 1, 2013. View at Google Scholar