Antihypercholesterolemic and Antioxidative Potential of an Extract of the Plant, Piper betle, and Its Active Constituent, Eugenol, in Triton WR-1339-Induced Hypercholesterolemia in Experimental Rats
Figure 1
Histoarchitecture of hepatic tissue Wistar rats. Sections of hepatic tissue from the experimental groups of rats were stained by H&E and then subjected to histopathological examination by light microscopy (Figure 1). Sections of hepatic tissue from control rats showing central vein with normal hepatocyte, healthy nucleus, and sinusoidal spaces with kupffer cells (arrows) (a). In sections from hypercholesterolemic saline-treated rats, revealing loss of normal liver radiating pattern, periportal inflammation with cellular infiltration in central vein (Marked place), and vacuolated hepatocytes (arrows) with the nucleus pushed to periphery (b). In hypercholesterolemic lovastatin-treated rats, section showed normal hepatocyte with darkly stained nucleus, (arrows) central vein and wide sinusoids (c). In hypercholesterolemic Piper betle extract-treated rats, section showed illustrating few small vacuolated hepatocytes with occasional inflammatory cell infiltration (d). In hypercholesterolemic eugenol-treated rats, sections showed normal hepatic architecture, with parenchymal structures preserved (e).
