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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 483294, 7 pages
http://dx.doi.org/10.1155/2014/483294
Review Article

Acupuncture Mechanism and Redox Equilibrium

1Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, China
2Acupuncture and Moxibustion College, Tianjin University of Traditional Chinese Medicine, No. 312, Anshan West Road, Nankai District, Tianjin 300193, China

Received 18 April 2014; Revised 17 June 2014; Accepted 25 June 2014; Published 7 July 2014

Academic Editor: Guang-Xia Shi

Copyright © 2014 Xiang-Hong Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Chrissobolis and F. M. Faraci, “The role of oxidative stress and NADPH oxidase in cerebrovascular disease,” Trends in Molecular Medicine, vol. 14, no. 11, pp. 495–502, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. D. P. Jones, “Radical-free biology of oxidative stress,” The American Journal of Physiology—Cell Physiology, vol. 295, no. 4, pp. C849–C868, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. S. R. Thomas, P. K. Witting, and G. R. Drummond, “Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities,” Antioxidants and Redox Signaling, vol. 10, no. 10, pp. 1713–1765, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Wu, “Acupuncture and stroke rehabilitation,” CMAJ, vol. 182, no. 16, pp. 1711–1712, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Wang, C. Z. Liu, J. C. Yu, W. Jiang, and J. X. Han, “Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus,” Physiology and Behavior, vol. 96, no. 1, pp. 155–161, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Shi, C. Liu, Q. Li, H. Zhu, and L. Wang, “Influence of acupuncture on cognitive function and markers of oxidative DNA damage in patients with vascular dementia,” Journal of Traditional Chinese Medicine, vol. 32, no. 2, pp. 199–202, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Liu, J. Yu, X. Zhang, W. Fu, T. Wang, and J. Han, “Acupuncture prevents cognitive deficits and oxidative stress in cerebral multi-infarction rats,” Neuroscience Letters, vol. 393, no. 1, pp. 45–50, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Orrenius, V. Gogvadze, and B. Zhivotovsky, “Mitochondrial oxidative stress: Implications for cell death,” Annual Review of Pharmacology and Toxicology, vol. 47, pp. 143–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Nunomura, P. I. Moreira, H. G. Lee et al., “Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases,” CNS and Neurological Disorders—Drug Targets, vol. 6, no. 6, pp. 411–423, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Sugawara and P. H. Chan, “Reactive Oxygen Radicals and Pathogenesis of Neuronal Death After Cerebral Ischemia,” Antioxidants and Redox Signaling, vol. 5, no. 5, pp. 597–607, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. J. H. Zhang, D. Wang, and M. Liu, “Overview of systematic reviews and meta-analyses of acupuncture for stroke,” Neuroepidemiology, vol. 42, no. 1, pp. 50–58, 2014. View at Publisher · View at Google Scholar
  12. J. Jittiwat and J. Wattanathorn, “Ginger pharmacopuncture improves cognitive impairment and oxidative stress following cerebral ischemia,” Journal of Acupuncture and Meridian Studies, vol. 5, no. 6, pp. 295–300, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. G. X. Shi, C. Z. Liu, L. P. Wang, L. P. Guan, and S. Q. Li, “Biomarkers of oxidative stress in vascular dementia patients,” The Canadian Journal of Neurological Sciences, vol. 39, no. 1, pp. 39–65, 2012. View at Google Scholar
  14. G. X. Shi, C. Z. Liu, Q. Q. Li, H. Zhu, and L. P. Wang, “Influence of acupuncture on cognitive function and markers of oxidative DNA damage in patients with vascular dementia,” Journal of Traditional Chinese Medicine, vol. 32, no. 2, pp. 199–202, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. F. K. W. Siu, S. C. L. Lo, and M. C. P. Leung, “Effectiveness of multiple pre-ischemia electro-acupuncture on attenuating lipid peroxidation induced by cerebral ischemia in adult rats,” Life Sciences, vol. 75, no. 11, pp. 1323–1332, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. F. K. W. Siu, S. C. L. Lo, and M. C. P. Leung, “Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains,” Neuroscience Letters, vol. 354, no. 2, pp. 158–162, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. C.-Z. Liu, Z.-G. Li, D.-J. Wang et al., “Effect of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats,” Neurological Sciences, vol. 34, no. 3, pp. 305–312, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Zhang, B. Wu, K. Nie, Y. Jia, and J. Yu, “Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats,” Neurochemistry International, vol. 65, pp. 23–29, 2014. View at Publisher · View at Google Scholar
  19. D. A. Butterfield, T. Koppal, B. Howard et al., “Structural and functional changes in proteins induced by free radical-mediated oxidative stress and protective action of the antioxidants N-tert-butyl-α-phenylnitrone and vitamin E,” Annals of the New York Academy of Sciences, vol. 854, pp. 448–462, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. E. R. Stadtman and B. S. Berlett, “Reactive oxygen-mediated protein oxidation in aging and disease,” Drug Metabolism Reviews, vol. 30, no. 2, pp. 225–243, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Nordberg and E. S. J. Arnér, “Reactive oxygen species, antioxidants, and the mammalian thioredoxin system,” Free Radical Biology and Medicine, vol. 31, no. 11, pp. 1287–1312, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. P. Lopert and M. Patel, “Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system,” The Journal of Biological Chemistry, vol. 289, pp. 15611–15620, 2014. View at Publisher · View at Google Scholar
  23. F. K. W. Siu, S. C. L. Lo, and M. C. P. Leung, “Electro-acupuncture potentiates the disulphide-reducing activities of thioredoxin system by increasing thioredoxin expression in ischemia-reperfused rat brains,” Life Sciences, vol. 77, no. 4, pp. 386–399, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. X. D. Chao, Y. H. Ma, P. Luo et al., “Up-regulation of Heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability,” Experimental Neurology, vol. 239, no. 1, pp. 163–169, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. H. Wang, W. Y. Wang, C. C. Chang et al., “Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation,” Journal of Biomedical Science, vol. 13, no. 1, pp. 127–141, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Y. Cheng, J. G. Lin, N. Y. Tang, S. T. Kao, and C. L. Hsieh, “Electroacupuncture-like stimulation at the Baihui (GV20) and Dazhui (GV14) acupoints protects rats against subacute-phase cerebral ischemia-reperfusion injuries by reducing S100B-mediated neurotoxicity,” PLoS ONE, vol. 9, no. 3, Article ID e91426, 2014. View at Publisher · View at Google Scholar
  27. S. Mondragón-Rodríguez, G. Perry, X. Zhu, and J. Boehm, “Amyloid beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy,” International Journal of Alzheimer's Disease, vol. 2012, Article ID 630182, 7 pages, 2012. View at Publisher · View at Google Scholar
  28. M. G. Savelieff, S. Lee, Y. Liu, and M. H. Lim, “Untangling amyloid-β, tau, and metals in Alzheimer's disease,” ACS Chemical Biology, vol. 8, no. 5, pp. 856–865, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Ellis, E. Fang, M. Maheshwari et al., “Lipid oxidation and modification of amyloid-β (Aβ) in vitro and in vivo.,” Journal of Alzheimer's Disease, vol. 22, no. 2, pp. 593–607, 2010. View at Google Scholar · View at Scopus
  30. Y. Zhao and B. Zhao, “Oxidative stress and the pathogenesis of Alzheimer's disease,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 316523, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. T. J. Montine, J. F. Quinn, D. Milatovic et al., “Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease,” Annals of Neurology, vol. 52, no. 2, pp. 175–179, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. S. Lee, B. C. Shin, and E. Ernst, “Acupuncture for Alzheimer's disease: a systematic review,” International Journal of Clinical Practice, vol. 63, no. 6, pp. 874–879, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Schroer and J. Adamson, “Acupuncture for depression: a critique of the evidence base,” CNS Neuroscience and Therapeutics, vol. 17, no. 5, pp. 398–410, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. B. Y. Zeng, S. Salvage, and P. Jenner, “Effect and mechanism of acupuncture on Alzheimer's disease,” International Review of Neurobiology, vol. 111, pp. 181–195, 2013. View at Google Scholar
  35. Z. Liu, W. Niu, X. Yang, and Y. Wang, “Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus in Alzheimer disease rats via olfactory system stimulation,” Journal of Traditional Chinese Medicine, vol. 33, no. 3, pp. 399–402, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Xue, Z. Zhang, L. Bai, H. Xu, and H. Wu, “Effect of electroacupuncture on the behavior and the expression of amyloid beta-protein, amyloid precursor protein and ChAT in APP 695 V 717 I transgenic mice,” Zhen Ci Yan Jiu, vol. 34, no. 3, pp. 152–158, 2009. View at Google Scholar · View at Scopus
  37. X. Ding, J. Yu, T. Yu, Y. Fu, and J. Han, “Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10),” Neuroscience Letters, vol. 399, no. 1-2, pp. 11–16, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. Z. B. Liu, W. M. Niu, X. H. Yang, X. .M. Niu, and Y. Wang, “Effect of “Xiusanzhen’ on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats,” Zhen Ci Yan Jiu, vol. 34, no. 1, pp. 48–51, 2009. View at Google Scholar · View at Scopus
  39. D. Praticò, Y. Yao, J. Rokach, M. Mayo, G. G. Silverberg, and D. McGuire, “Reduction of brain lipid peroxidation by CSF drainage in Alzheimer's disease patients,” Journal of Alzheimer's Disease, vol. 6, no. 4, pp. 385–389, 2004. View at Google Scholar · View at Scopus
  40. H. Zhu, K. Dong, Y. Wu et al., “Influence of acupuncture on isoprostane in patients with Alzheimer's disease,” Zhongguo Zhen Jiu, vol. 30, no. 1, pp. 18–21, 2010. View at Google Scholar · View at Scopus
  41. S. Choi, S. Aid, H. Kim, S. H. Jackson, and F. Bosetti, “Inhibition of NADPH oxidase promotes alternative and anti-inflammatory microglial activation during neuroinflammation,” Journal of Neurochemistry, vol. 120, no. 2, pp. 292–301, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Chen, J. Zhou, J. Li et al., “Electroacupuncture pretreatment prevents cognitive impairment induced by limb ischemia-reperfusion via inhibition of microglial activation and attenuation of oxidative stress in rats,” Brain Research, vol. 1432, pp. 36–45, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. D. C. Choi, J. Y. Lee, Y. J. Moon, S. W. Kim, T. H. Oh, and T. Y. Yune, “Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury,” Neurobiology of Disease, vol. 39, no. 3, pp. 272–282, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Varçin, E. Bentea, Y. Michotte, and S. Sarre, “Oxidative stress in genetic mouse models of Parkinson's disease.,” Oxidative medicine and cellular longevity, vol. 2012, Article ID 624925, 25 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. J. Boada, B. Cutillas, T. Roig, J. Bermúdez, and S. Ambrosio, “MPP+-induced mitochondrial dysfunction is potentiated by dopamine,” Biochemical and Biophysical Research Communications, vol. 268, no. 3, pp. 916–920, 2000. View at Publisher · View at Google Scholar · View at Scopus
  46. P. C. Keane, M. Kurzawa, P. G. Blain, and C. M. Morris, “Mitochondrial dysfunction in Parkinson's disease,” Parkinson's Disease, vol. 2011, Article ID 716871, 18 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. I. Cacciatore, L. Baldassarre, E. Fornasari, A. Mollica, and F. Pinnen, “Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems,” Oxidative Medicine and Cellular Longevity, vol. 2012, Article ID 240146, 12 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. T. H. Joh, H. Park, S. Kim, and H. Lee, “Recent development of acupuncture on Parkinson's disease,” Neurological Research, vol. 32, no. 1, pp. S5–S9, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. Y.-P. Yu, W.-P. Ju, Z.-G. Li, D.-Z. Wang, Y.-C. Wang, and A.-M. Xie, “Acupuncture inhibits oxidative stress and rotational behavior in 6-hydroxydopamine lesioned rat,” Brain Research, vol. 1336, pp. 58–65, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Wang, Y. Pan, B. Xue et al., “The antioxidative effect of electro-acupuncture in a mouse model of Parkinson's disease,” PLoS ONE, vol. 6, no. 5, Article ID e19790, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Kim, W. Moon, Y. Chae, Y. J. Kim, H. Lee, and H. Park, “The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced proteomic changes in the mouse striatum,” The Journal of Physiological Sciences, vol. 60, no. 1, pp. 27–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. J. R. Connor and S. A. Benkovic, “Iron regulation in the brain: histochemical, biochemical, and molecular considerations,” Annals of Neurology, vol. 32, pp. S51–S61, 1992. View at Publisher · View at Google Scholar · View at Scopus
  53. T. Moos and E. H. Morgan, “The metabolism of neuronal iron and its pathogenic role in neurological disease review,” Annals of the New York Academy of Sciences, vol. 1012, pp. 14–26, 2004. View at Publisher · View at Google Scholar · View at Scopus
  54. E. Sofic, P. Riederer, H. Heinsen et al., “Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain,” Journal of Neural Transmission, vol. 74, no. 3, pp. 199–205, 1988. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Mandel, G. Maor, and M. B. H. Youdim, “Iron and α-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate,” Journal of Molecular Neuroscience, vol. 24, no. 3, pp. 401–416, 2004. View at Publisher · View at Google Scholar · View at Scopus
  56. J. Wang, H. Jiang, and J.-X. Xie, “Time dependent effects of 6-OHDA lesions on iron level and neuronal loss in rat nigrostriatal system,” Neurochemical Research, vol. 29, no. 12, pp. 2239–2243, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Yeo, Y. Choi, Y. Hong, and S. Lim, “Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: microarray analysis,” Gene, vol. 515, no. 2, pp. 329–338, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. J. A. Engelman, J. Luo, and L. C. Cantley, “The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism,” Nature Reviews Genetics, vol. 7, no. 8, pp. 606–619, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. S. T. Kim, W. Moon, Y. Chae, Y. J. Kim, H. Lee, and H. Park, “The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced proteomic changes in the mouse striatum,” Journal of Physiological Sciences, vol. 60, no. 1, pp. 27–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. S.-N. Kim, A.-R. Doo, J.-Y. Park et al., “Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease,” PLoS ONE, vol. 6, no. 11, Article ID e27566, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. Y. Kim, H. Lim, Y. Song et al., “Effect of acupuncture on 6-hydroxydopamine-induced nigrostratal dopaminergic neuronal cell death in rats,” Neuroscience Letters, vol. 384, no. 1-2, pp. 133–138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. X. Y. Liu, H. F. Zhou, Y. L. Pan et al., “Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats,” Experimental Neurology, vol. 189, no. 1, pp. 189–196, 2004. View at Publisher · View at Google Scholar · View at Scopus
  63. J. M. Kang, H. J. Park, Y. G. Choi et al., “Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model,” Brain Research, vol. 1131, no. 1, pp. 211–219, 2007. View at Publisher · View at Google Scholar · View at Scopus
  64. S. H. H. Chan, M. Tai, C. Li, and J. Y. H. Chan, “Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats,” Free Radical Biology and Medicine, vol. 40, no. 11, pp. 2028–2039, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. S. H. Chan and J. Y. Chan, “Brain stem NOS and ROS in neural mechanisms of hypertension,” Antioxidants & Redox Signaling, vol. 20, pp. 146–163, 2014. View at Google Scholar
  66. R. Rodrigo, J. González, and F. Paoletto, “The role of oxidative stress in the pathophysiology of hypertension,” Hypertension Research, vol. 34, no. 4, pp. 431–440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. R. M. Touyz and A. M. Briones, “Reactive oxygen species and vascular biology: implications in human hypertension,” Hypertension Research, vol. 34, no. 1, pp. 5–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  68. M. Majzunova, I. Dovinova, M. Barancik, and J. Y. Chan, “Redox signaling in pathophysiology of hypertension,” Journal of Biomedical Science, vol. 20, article 69, 2013. View at Publisher · View at Google Scholar
  69. D. Z. Li, Y. Zhou, Y. Yang et al., “Acupuncture for essential hypertension: a meta-analysis of randomized sham-controlled clinical trials,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 279478, 7 pages, 2014. View at Publisher · View at Google Scholar
  70. J. Wang, X. Xiong, and W. Liu, “Acupuncture for essential hypertension,” International Journal of Cardiology, vol. 169, no. 5, pp. 317–326, 2013. View at Publisher · View at Google Scholar
  71. X. Lai, J. Wang, N. R. Nabar et al., “Proteomic response to acupuncture treatment in spontaneously hypertensive rats,” PLoS ONE, vol. 7, no. 9, Article ID e44216, 2012. View at Publisher · View at Google Scholar · View at Scopus
  72. C. Zhang, C. Xia, M. Jiang et al., “Repeated electroacupuncture attenuating of apelin expression and function in the rostral ventrolateral medulla in stress-induced hypertensive rats,” Brain Research Bulletin, vol. 97, pp. 53–62, 2013. View at Publisher · View at Google Scholar · View at Scopus
  73. Y. Oh, E. J. Yang, S. Choi, and C. Kang, “The effect of electroacupuncture on insulin-like growth factor-I and oxidative stress in an animal model of renal failure-induced hypertension,” Kidney and Blood Pressure Research, vol. 35, no. 6, pp. 634–643, 2013. View at Publisher · View at Google Scholar · View at Scopus
  74. Y. L. Jiang, Y. Ning, Y. Y. Liu et al., “Effects of preventive acupuncture on streptozotocin-induced hyperglycemia in rats,” Journal of Endocrinological Investigation, vol. 34, no. 10, pp. e355–e361, 2011. View at Google Scholar · View at Scopus
  75. L. Li, G. Tan, and Y. Zhang, “Modulated expression of genes associated with NO signal transduction contributes to the cholesterol-lowering effect of electro-acupuncture,” Biotechnology Letters, vol. 34, no. 7, pp. 1175–1182, 2012. View at Publisher · View at Google Scholar · View at Scopus
  76. H. S. Hwang, K.-J. Han, Y. H. Ryu et al., “Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats,” World Journal of Gastroenterology, vol. 15, no. 8, pp. 973–977, 2009. View at Publisher · View at Google Scholar · View at Scopus
  77. C. Huang, P. Tsai, T. Wang, L. Yan, and H. Xu, “Acupuncture stimulation of ST36 (Zusanli) attenuates acute renal but not hepatic injury in lipopolysaccharide-stimulated rats,” Anesthesia and Analgesia, vol. 104, no. 3, pp. 646–654, 2007. View at Publisher · View at Google Scholar · View at Scopus
  78. E. L. W. Santos, B. H. M. Dias, A. C. R. de Andrade et al., “Effects of acupuncture and electroacupuncture on estradiol-induced inflammation and oxidative stress in health rodents,” Acta Cirurgica Brasileira, vol. 28, no. 8, pp. 582–588, 2013. View at Publisher · View at Google Scholar · View at Scopus
  79. A. H. Silva, L. M. Figueiredo, P. A. Dias, A. X. do Prado Neto, P. R. L. de Vasconcelos, and S. B. Guimarães, “Electroacupuncture attenuates liver and kidney oxidative stress in anesthetized rats,” Acta Cirurgica Brasileira, vol. 26, supplement 1, pp. 60–65, 2011. View at Publisher · View at Google Scholar · View at Scopus
  80. S. Rho, G. Choi, E. Ko et al., “Molecular changes in remote tissues induced by electro-acupuncture stimulation at acupoint ST36,” Molecules and Cells, vol. 25, no. 2, pp. 178–183, 2008. View at Google Scholar · View at Scopus
  81. L. Picanço Lima, A. De Oliveira Albuquerque, J. J. De Lima Silva, F. Das Chagas Medeiros, P. R. L. De Vasconcelos, and S. Botelho Guimarães, “Electroacupuncture attenuates oxidative stress in random skin flaps in rats,” Aesthetic Plastic Surgery, vol. 36, no. 5, pp. 1230–1235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  82. D. C. Choi, J. Y. Lee, E. J. Lim, H. H. Baik, T. H. Oh, and T. Y. Yune, “Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats,” Experimental Neurology, vol. 236, no. 2, pp. 268–282, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. K. Moore and L. J. Roberts II, “Effects of intracellular superoxide removal at acupoints with TAT-SOD on obesity,” Free Radical Biology and Medicine, vol. 51, no. 12, p. 2163, 2011. View at Publisher · View at Google Scholar · View at Scopus