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Research Article
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 721341, 2 pages
http://dx.doi.org/10.1155/2014/721341
Erratum

Erratum to “PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn”

1Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-sen University, 132 Waihuan Dong Road, Guangzhou 510006, China
2School of Pharmaceutical Sciences, Hainan Medical University, Haikou 571010, China
3Institute of Chinese Medical Sciences, Macau University, Macau 999078, China

Received 25 June 2014; Accepted 20 July 2014; Published 28 October 2014

Copyright © 2014 Ling Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Figure 3(a) was incorrectly published in the original paper titled ‘‘PXR-mediated upregulation of CYP3A expression by herb compound praeruptorin C from Peucedanum praeruptorum Dunn.’’ The corrected figure is attached below. The hPXR mRNA expression in LS174T cells was remarkably increased to 675-fold after transfection with pSG5-hPXR expression plasmid.

721341.fig.001
Figure 3: Effects of PC on the expression of CYP3A4 mRNA in LS174T cells. (a) LS174T cells were transfected with hPXR expression plasmids for 6 h. Total RNA of LS174T cells was isolated, and hPXR mRNA levels were analyzed by real-time PCR. The effect of herbal compounds on hPXR mRNA levels is presented as fold mRNA expression to control vehicle treated cells. (b) LS174T cells were transfected with hPXR expression plasmids for 6 h. The cells were treated with vehicle control (0.1% DMSO); 10 μM CITCO; and 2.5, 10, and 40 μM PC for 48 h, respectively. The CYP3A4 mRNA levels were analyzed by real-time PCR. The effect of herbal compounds on CYP3A4 mRNA levels is presented as fold mRNA expression to control vehicle treated cells. , for comparison with the control groups. Values are expressed as mean ± S.E.M ().