Evidence-Based Complementary and Alternative Medicine

Evidence-Based Complementary and Alternative Medicine / 2015 / Article
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Evidence Based Alternative Medicines in Pain Management

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Research Article | Open Access

Volume 2015 |Article ID 179731 | https://doi.org/10.1155/2015/179731

Yen-Ting Liu, Chih-Wen Chiu, Chin-Fu Chang, Tsung-Chieh Lee, Chia-Yun Chen, Shun-Chang Chang, Chia-Ying Lee, Lun-Chien Lo, "Efficacy and Safety of Acupuncture for Acute Low Back Pain in Emergency Department: A Pilot Cohort Study", Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 179731, 8 pages, 2015. https://doi.org/10.1155/2015/179731

Efficacy and Safety of Acupuncture for Acute Low Back Pain in Emergency Department: A Pilot Cohort Study

Academic Editor: Haroon Khan
Received26 Dec 2014
Revised17 Feb 2015
Accepted17 Feb 2015
Published04 Aug 2015

Abstract

Introduction. Low back pain (LBP) is one of the most common complaints in the emergency department (ED). There are several research articles providing evidence for acupuncture for treating chronic LBP but few about treating acute LBP. This study assessed the efficacy and safety of acupuncture for the treatment of acute LBP in the ED. Materials and methods. A clinical pilot cohort study was conducted. 60 participants, recruited in the ED, were divided into experimental and control groups with 1 dropout during the study. Life-threatening conditions or severe neurological defects were excluded. The experimental group () received a series of fixed points of acupuncture. The control group () received sham acupuncture by pasting seed-patches near acupoints. Back pain was measured using the visual analog scale (VAS) at three time points: baseline and immediately after and 3 days after intervention as the primary outcome. The secondary outcomes were heart rate variability (HRV) and adverse events. Results. The VAS demonstrated a significant decrease ( value <0.001) for the experimental group after 15 minutes of acupuncture. The variation in HRV showed no significant difference in either group. No adverse event was reported. Conclusion. Acupuncture might provide immediate effect in reducing the pain of acute LBP safely.

1. Introduction

Most adults have the experience of low back pain (LBP) in their lives [1, 2]. Low back pain is one of the most common complaints when patients visit the emergency department (ED) [3, 4]. Most cases of acute LBP are not related to any specific disease [57]. After checking the patients and excluding any life-threatening conditions or severe neurological deficits, sometimes the pain has still not been eased. Patients must be kept in the ED for further observation. The prolonged hospital stay due to poor pain control is a potential factor that can cause the overcrowding of the ED [8].

Pain has been regarded as the fifth vital sign (temperature, heart rate, blood pressure, and respiratory rate) recently [9], and every patient has the right to receive adequate pain management. Pain relief is an important work in the ED and there are many medications for LBP with each medication having both benefits and side effects [1013].

Acupuncture is one of the oldest and most popular complementary alternative medicines in the world and it has been widely utilized for pain, including low back pain, osteoarthritis, headache, and cancer [1419]. We found that there are many studies assessing the effectiveness of acupuncture for chronic LBP but few for acute LBP [15, 20].

In light of the aforementioned observation, this study focused on evaluating the efficacy and safety of acupuncture in patients with acute LBP through outpatient care in the ED.

2. Materials and Methods

2.1. Population

A clinical pilot cohort study was conducted. Patients were recruited from the emergency department (ED) of Changhua Christian Hospital (a medical center in Taiwan) with a target sample size of 60 subjects. Participants were divided into either the experimental group or control group based on their willingness to accept acupuncture treatment. All candidates received a standardized interview process. And the purpose, procedures, potential risks, and benefits of the study were explained thoroughly to the candidates. Participants had the right to withdraw from the study at any time without any consequence. All participants’ written consents were obtained. The trial was conducted from March to December, 2014. The clinical trial protocol was approved by the Institute Review Board (IRB) of Changhua Christian Hospital (CCH IRB number 140214).

2.2. Inclusion Criteria

Participants meeting all of the following criteria will be included:(1)age 20 to 90 years, either gender;(2)visit and stay in emergency department;(3)the chief complaint being acute low back pain;(4)diagnosis with International Classification of Diseases 9th revision (ICD-9) code 724.2 Lumbago.

2.3. Exclusion Criteria

Participants meeting one or more of the following criteria were excluded:(1)serious comorbid conditions (e.g., life-threatening condition or severe neurological defects);(2)patients who cannot communicate reliably with the investigator or who are not likely to obey the instructions of the trial;(3)pregnancy status.

2.4. Baseline Assessment
2.4.1. The Oswestry Disability Index (ODI)

This questionnaire (also known as Oswestry Low Back Pain Disability Questionnaire) was designed to measure a patient’s functional disability resulting from spinal pain [21].

2.5. Interventions

Participants were divided into experimental and control groups based on their willingness to accept acupuncture treatment. The experimental group received a series of fixed points of acupuncture: Bilateral Hegu (LI4), Shousanli (LI10), Zusanli (ST36), Yanlingquan (GB34), and Taichong (LR3) [22]. Needles were correctly inserted and manually stimulated until the “De Qi” sensation was elicited. The needles stayed in place for 15 minutes. The control group received sham acupuncture by pasting seed-patches next to the same location as correct acupoints of experimental group; see Figure 2 [22].

2.6. Evaluations

The primary outcome evaluation was the visual analog scale (VAS) for pain. It is graded from 0 (no pain) to 10 (worst possible pain) and has proven its usefulness and clinical validity for the evaluation of pain [23]. Patients were evaluated at three timepoints in this study: before intervention (VAS-1), after intervention (VAS-2), 3 days after the intervention (VAS-3).

The secondary outcomes were heart rate variability (HRV) and adverse events. HRV was measured 2 times in this study: before the intervention and after the intervention. Many studies have shown a relation between HRV and pain [24, 25]. We tried to further identify the correlation between the intensity of pain and HRV [26, 27]. An additional secondary outcome was participants reporting any adverse events they experience, including discomfort, bruising at the sites of needle insertion, nausea, or feeling faint during or after treatment.

2.7. Data Analysis

First, the experimental group and control group were analyzed for comparability according to the baseline characteristics, including gender, age, body mass index (BMI), blood pressure (systole and diastole), heart rate (HR), and ODI. Chi-square test and Mann-Whitney test were used to assess categorical variables. Second, in order to analyse the outcome of this study including VAS and HRV, we used Wilcoxon Signed Ranks Test and Mann-Whitney test because of the sample size. All tests were conducted using SPSS (V.18.0).

3. Results

The flowchart of this study is presented in Figure 1.

Participant Recruitment. All study participants, from the emergency department (ED), were evaluated by emergency medicine specialists to exclude serious comorbid conditions and severe neurological defects, such as infection, cauda equina syndrome, and aneurysm. Sixty participants (21–89 years old, 20 men and 40 women) were recruited into the study and divided into experimental group () and control group (). The VAS was conducted to evaluate the maintenance of the pain relieving effect by phone interview 3 days after treatment. There was 1 participant lost to follow-up in the experimental group at the 3 days after intervention timepoint.

Baseline Characteristics. Tables 1(a) and 1(b) show baseline participant characteristics, including gender, age, BMI, blood pressure, heart rate, and Oswestry Disability Index. The two groups were homogeneous while no significant difference was shown at baseline assessment.

(a)

 ControlAcupunctureP value
 %%

Gender14450.942
 Female7 50.0 23 51.1  
 Male7 50.0 22 48.9

value by Chi-square test.
(b)

  Control () Acupuncture () value
 
 MedianMedian

Age65 52 79 56 46 75 0.423
BMI26 23 28 24 22 27 0.454
SYS134 119 137 122 117 138 0.741
DIA76 73 78 74 71 79 0.533
HR81 77 91 75 67 88 0.303
Oswestry
 () Pain intensity3 2 4 3 3 4 0.861
 () Personal care2 1 5 3 2 4 0.930
 () Lifting5 5 5 4 3 5 0.024
 () Walking4 3 5 4 3 5 0.767
 () Sitting4 2 5 4 3 5 0.745
 () Standing4 3 5 4 1 4 0.099
 () Sleeping2 1 4 3 1 4 0.648
 () Sex life4 4 4 4 2 4 0.448
 () Social life4 3 5 4 3 5 0.205
 () Traveling5 3 5 5 3 5 0.853

value by Mann-Whitney test.
: Percentile 25.
: Percentile 75.
BMI, body mass index; SYS, systolic pressure; DIA, diastolic pressure; HR, heart rate.

VAS. Comparison of VAS-1 (before intervention) and VAS-2 (after intervention) indicated that there was significant difference in the experimental group () but not in control group (). Comparison of VAS-1 and VAS-3 (3 days after intervention) found significant differences in both experimental group () and control group () (see Table 2).


  Control ()Acupuncture () valueb
 Median valueaMedian valuea

VAS-15.5 4 7 7.0 5 8 0.059
VAS-24.5 4 6 0.109 4.0 2 5 <0.0010.161
VAS-33.0 0 4 0.0113.0 1 6 <0.0010.465

valuea by Wilcoxon Signed Ranks Test (take VAS1 as reference) (intergroup).
valueb by Mann-Whitney test (between groups).
: Percentile 25.
: Percentile 75.
VAS-1, VAS before intervention; VAS-2, VAS after intervention; VAS-3, VAS of 3 days after intervention.
Statistically significant difference ().

In addition, comparison of VAS1-VAS2 (changes of VAS-1 and VAS-2) between two groups also showed a significant difference (). No significant difference was observed in VAS1-VAS3 (changes of VAS-1 and VAS-3) () and VAS2-VAS3 (changes of VAS-2 and VAS-3) () (see Table 3).


Control ()Acupuncture () value
MedianMedian

ΔVAS2-VAS10.0 0 0 −2.0 −4 −1 <0.001
ΔVAS3-VAS1−1.5 −3 0 −4.0 −5 −1 0.370
ΔVAS3-VAS2−1.5 −3 0 −1.0 −3 2 0.181

value by Mann-Whitney test.
: Percentile 25.
: Percentile 75.
Statistically significant difference ().
ΔVAS2-VAS1, changes of VAS-2 and VAS-1; ΔVAS3-VAS1, changes of VAS-3 and VAS-1; ΔVAS3-VAS2, changes of VAS-3 and VAS-2.

Furthermore, when we do the gamma regression model with GEE method on VAS, the results also indicate a significant change after treatment in the experimental group () but not in the control group. The VAS reduced significantly in all patients after 3 days () (see Table 5).

HRV. Table 4 shows the comparison of all parameters of HRV before and after intervention in experimental group and control group. No significant change was observed in HRV, HF%, LF%, LF/HF, VLF, LF RMSSD, and PNN50 in both groups in this study.


Group BeforeAfter value
 MedianMedian

Control
()
HRV39.0 33.0 49.0 31.0 26.0 45.0 0.311
HF%50.0 38.0 58.0 53.0 48.0 76.0 0.421
LF%50.0 42.0 62.0 47.0 24.0 52.0 0.421
LF/HF1.0 0.7 1.6 0.9 0.3 1.1 0.133
VLF976.0 567.0 1436.0 628.0 501.0 1098.0 0.463
Number of irreg. hb.8.0 0.0 48.0 2.0 0.0 13.0 0.229
LF305.0 92.0 509.0 154.0 54.0 199.0 0.552
HF258.0 196.0 323.0 224.0 133.0 428.0 0.916
Total power1521.0 1089.0 2401.0 961.0 676.0 2025.0 0.311
Variance1521.0 1089.0 2401.0 961.0 676.0 2025.0 0.311
RMSSD45.0 29.0 52.0 41.0 22.0 54.0 0.674
PNN5013.0 8.0 30.0 20.0 1.0 30.0 0.753

Acupuncture
()
HRV40.0 25.0 83.0 34.0 24.0 58.0 0.273
HF%45.0 32.0 61.0 46.0 32.0 60.0 0.694
LF%55.0 39.0 68.0 53.0 39.0 68.0 0.905
LF/HF1.2 0.6 2.1 1.1 0.7 2.1 0.923
VLF891.0 382.0 4272.0 732.0 423.0 2274.0 0.561
Number of irreg. hb.11.0 0.0 49.0 6.5 0.0 22.0 0.158
LF204.0 77.0 1095.0 185.0 53.0 667.0 0.891
HF208.0 68.0 932.0 141.5 71.0 503.0 0.446
Total power1600.0 625.0 6889.0 1157.0 576.0 3364.0 0.401
Variance1600.0 625.0 6889.0 1157.0 576.0 3364.0 0.401
RMSSD34.0 22.0 75.0 32.0 22.0 59.0 0.573
PNN5011.0 1.0 45.0 8.5 2.0 31.0 0.353

value by Wilcoxon Signed Ranks Test.
: Percentile 25.
: Percentile 75.
HF, high frequency; LF, low frequency; VLF, very low frequency; Number of irreg. hb., number of irregular heart beats; RMSSD, root mean square successive difference; PNN50, NN50 count divided by the total number of all NN intervals.

PredictorCoefficientSEMean ratio95% C.I. value

(Intercept)1.701 0.368 5.478 2.665–11.259 <0.001
Age0.001 0.002 1.001 0.997–1.005 0.637
BMI−0.001 0.012 0.999 0.977–1.0220.920
Gender
 Male0.008 0.096 1.008 0.835–1.215 0.936
 Female0.000 1.000
Group
 Acupuncture0.156 0.098 1.169 0.964–1.417 0.113
 Control0.000 1.000
Time
 3−0.377 0.175 0.686 0.487–0.966 0.031
 2−0.132 0.077 0.876 0.753–1.0190.086
 10.000 1.000
Interaction
 Acupuncture Time 30.021 0.196 1.021 0.695–1.499 0.916
 Acupuncture Time 2−0.380 0.092 0.684 0.571–0.819<0.001
 Acupuncture Time 10.000 1.000
 Control Time 30.000 1.000
 Control Time 20.000 1.000
 Control Time 10.000 1.000

Statistically significant difference ().

Adverse Events. No side effects were reported in this study. No patients reported bleeding, nausea, vomiting, feeling faint, or any other complication during or after intervention.

4. Discussion

This study was designed to demonstrate that acupuncture can benefit patients with acute LBP. Instead of recruiting participants from acupuncture outpatients, we cooperated with emergency medicine specialists in order to make the first contact with patients with acute LBP. Clinically we found that most patients with acute LBP would not be able to maintain the face-down posture during the treatment time. Therefore, all the acupoints we chose in this study were at the limbs and based on traditional Chinese medical meridian system, so patients could keep a relatively comfortable lying down position.

In the results of this study, the significant difference between VAS-1 and VAS-2 in the experimental group might prove the efficacy of acupuncture while no statistical variation was shown in control group. Another significant variation was shown in the change of VAS-1 and VAS-2 (VAS1-VAS2) between two groups. It also indicated that acupuncture intervention might reduce the pain intensity. The other significant variation was between VAS-1 and VAS-3 in both groups. And it was considered as acute LBP could be mitigated through appropriate treatment without immediate recurrence [28].

HRV measures the balance of autonomic nervous system which reflects physiological, hormonal, and emotional balance within our body [29]. Many studies have proved that there are statistical differences of HRV between healthy people and patients in pain [24, 30]. But the correlation between HRV and pain intensity has not been clearly demonstrated [24, 31]. In our study, no significant difference was shown in both experimental and control group after intervention. We assume that patients might feel much less pain after 15 minutes of acupuncture (mean to ) but have not yet fully recovered to pain-free state.

We used the adverse event record to assess the safety. No complication was reported showing that acupuncture could be a safe treatment in patients with acute LBP. However, our study has several limitations. One limitation concerned the different number of participants between two groups. Acupuncture is a common and popular medical service in the Chinese society. Patients are usually willing to accept it. It resulted in the fact that less participants were recruited into control group when our strategy was to divide participants into two groups based on their willingness to accept acupuncture.

Another limitation was that this study was not designed as randomized blind. Considering that acupuncture is well-known in the Chinese society, it is difficult to do blinded study about acupuncture. In order to minimize the bias from this, we used seed-patches as sham acupuncture. Seed-patches are often used in auricular acupuncture. Auricular acupuncture is another well-known Chinese medical service. We tried to convince participants in control group that they were also receiving another effective treatment by pasting the seed-patches near the correct acupoints [32, 33]. Still, biases introduced by this unblinded approach cannot be ruled out.

A larger sample size in future studies is indispensable to provide well-defined types of acute low back pain for our evidence-based practice.

5. Conclusion

We conclude that acupuncture could provide immediate effect in reducing pain of acute low back pain significantly. The results from this study provide clinical evidence on the efficacy and safety of acupuncture to treat acute low back pain in the emergency department. Nevertheless, further larger studies are needed to replicate the findings of this study.

Conflict of Interests

The authors declare that they have no conflict of interests.

Authors’ Contribution

Yen-Ting Liu collected the data, did the literature search, and drafted the paper. Yen-Ting Liu, Chih-Wen Chiu, Chin-Fu Chang, Tsung-Chieh Lee, Chia-Yun Chen, Shun-Chang Chang, Chia-Ying Lee, and Lun-Chien Lo participated in the conception and design of the study. Tsung-Chieh Lee, Chia-Yun Chen, Shun-Chang Chang, and Chia-Ying Lee conducted acupuncture treatment and seed-patches. Lun-Chien Lo did the critical revision of the paper and was the corresponding author.

Acknowledgments

This study was supported by the Ministry of Health and Welfare, Taiwan (Program no. MOHW-103-CMC-2). The authors would like to thank all of the participants.

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Copyright © 2015 Yen-Ting Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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