Keishibukuryogan, a Traditional Japanese Medicine, Inhibits Platelet Aggregation in Guinea Pig Whole Blood
Effects of constituent crude drugs of KBG on collagen-induced platelet aggregation of guinea pig whole blood. (a) Effects of 5 crude drugs (40–1000 μg/mL) on 4 μg/mL collagen-induced increase in pressure rates. (b) Effects of 3 crude drugs (200 μg/mL) on collagen-induced increase (1–8 μg/mL) in pressure rates. (c) PATI values for 3 crude drugs. Data are expressed as the mean ± SEM (-10 animals). Significant differences in each group of (a) data were evaluated using one-way ANOVA followed by a post hoc Dunnett’s multiple comparison test: , , and versus vehicle. The data in (b) was evaluated using two-way ANOVA followed by a post hoc Bonferroni multiple comparison test. Significant difference was observed in Moutan cortex group () and Cinnamomi cortex group () compared to control group. Post hoc analysis was performed at each concentration of collagen: . The data in Figure 4(c) was evaluated using the unpaired Student’s -test: versus vehicle.
(a) Pressure rate: 5 crude drugs
(b) Pressure rate: 3 crude drugs
(c) PATI value: 3 crude drugs
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