Involvement of Cholinergic and Opioid System in γ-Terpinene-Mediated Antinociception

Figure 5

Effect of the γ-TPN (3.125 mg/kg, p.o.) against the action of atropine (1 mg/kg, i.p.) (a) and mecamylamine (2 mg/kg, i.p.) (b) on glutamate-induced nociception (20 μL, 20 μmol/paw) in mice. Data represent mean ± SEM of 6–9 mice. In Figure 5(a), the symbols indicate the level of significance: compared with vehicle, compared with the pilocarpine group, and compared with γ-TPN group. In Figure 5(b), compared with vehicle, compared with the nicotine group, compared with γ-TPN group; + presents treatment; − presents missing treatment (one-way analysis of variance, Bonferroni’s test).

(a)

(b)