Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro

Table 2

Combination index (CI) at ED₇₀, ED₇₅, and ED₉₀ values with drug combination on inhibiting Ca²⁺ response to agonists. The CI values at Fa value of 0.70, 0.75, and 0.90 for isobolograms (Figure 3) were calculated with the Calcusyn version 2.1 software.

		ED70	ED75	ED90
WS-12	FA : lig (8.3 : 7.8)	0.16218	0.16971	0.22336
ASP 7663	FA : lig (9.1 : 6.8)	0.26528	0.2655	0.2848