Cardiovascular Effects of the Essential Oil of Croton argyrophylloides in Normotensive Rats: Role of the Autonomic Nervous System

Figure 1

Maximal changes in mean aortic pressure (ΔMAP max, (a)) and heart rate (ΔHR max, (b)) elicited by intravenous (i.v.) injections of increasing bolus doses (1–20 mg/kg) of the essential oil of Croton argyrophylloides (EOCA) in pentobarbital-anesthetized rats with or without bilateral vagotomy and in conscious saline-pretreated rats. Values are means of changes expressed as a percentage of baseline values. Vertical bars indicate SEM (5-6 rats per group). The dose-hypotensive and dose-tachycardiac response curves for conscious rats pretreated with saline (from Figure 2) were included here for comparison with those for intact, anesthetized rats. by Dunnett’s test with respect to basal values. by two-way ANOVA with respect to intact or bivagotomized, anesthetized rats.

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