Synergism Effect of the Essential Oil from Ocimum basilicum var. Maria Bonita and Its Major Components with Fluconazole and Its Influence on Ergosterol Biosynthesis

Table 1

Evaluation of interaction resulting from the combination of the substances tested by determining the FI using the checkerboard technique.

Strain	MIC (µg/mL)				MIC in combination (µg/mL)
	EO	L	G	FLC	FLC	EO	FIC; index	FLC	L	FIC; index	FLC	G	FIC; index	L	G	FIC; index
C. neoformans	1250	790	76	31.25	4.14	625	0.633; (I)	8.054	197	0.5077; (I)	4.14	19	0.3826; (S)	111	19	0.3905; (S)
C. albicans resistant	1250	1580	152	500	1.01	156	0.127; (S)	2.02	197	0.134; (S)	1.04	38	0.252; (S)	397	4.8	0.284; (S)
C. albicans sensitive	1250	790	152	0.975	0.259	312	0.51; (I)	0.065	395	0.57; (I)	0.259	38	0.51; (I)	105	38	0.38; (S)

L: linalool; G: geraniol; FLC: fluconazole;  FIC index: fractional inhibitory concentration index; I: indifferent; S: synergist.