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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 2979760, 15 pages
https://doi.org/10.1155/2017/2979760
Research Article

Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats

1Laboratory of Preventive and Integrative Biomedicine, Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
2Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia
3Veterinary Drug Residue Analysis Division, Institute of Food & Radiation Biology, Atomic Energy Research Establishment, Savar, Dhaka 1349, Bangladesh
4Department of Biochemistry, Primeasia University, Banani, Dhaka 1213, Bangladesh
5Wazed Miah Science Research Center, Jahangirnagar University, Dhaka 1342, Bangladesh
6Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia

Correspondence should be addressed to Md. Ibrahim Khalil; moc.liamg@lilahkimrd

Received 18 June 2017; Revised 21 August 2017; Accepted 12 September 2017; Published 19 October 2017

Academic Editor: Dinesh Dhamecha

Copyright © 2017 Md. Yousuf Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Assal and L. Groop, Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications, World Health Organization, Geneva, Switzerland, 1999.
  2. H. King, R. E. Aubert, and W. H. Herman, “Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections,” Diabetes Care, vol. 21, no. 9, pp. 1414–1431, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. A. F. Amos, D. J. McCarty, and P. Zimmet, “The rising global burden of diabetes and its complications: estimates and projections to the year 2010,” Diabetic Medicine, vol. 14, no. 5, pp. S7–S85, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Rajalakshmi, J. Eliza, C. E. Priya, A. Nirmala, and P. Daisy, “Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin- induced diabetic rats,” African Journal of Pharmacy and Pharmacology, vol. 3, no. 5, pp. 171–180, 2009. View at Google Scholar · View at Scopus
  5. J. Deruiter, “Overview of the antidiabetic agents,” Endocrine Pharmacotherapy Module, p. 33, 2003. View at Google Scholar
  6. B. Lorenzati, C. Zucco, S. Miglietta, F. Lamberti, and G. Bruno, “Oral hypoglycemic drugs: Pathophysiological basis of their mechanism of action,” Pharmaceuticals, vol. 3, no. 9, pp. 3005–3020, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Rajagopal and K. Sasikala, “Antihyperglycaemic and antihyperlipidaemic effects of Nymphaea stellata in alloxan-induced diabetic rats,” Singapore Medical Journal, vol. 49, no. 2, pp. 137–141, 2008. View at Google Scholar · View at Scopus
  8. M. Valiathan, “Healing plants,” Current Science, vol. 75, no. 9, pp. 1122–1126, 1998. View at Google Scholar
  9. M. Z. Islam, M. M. Hoque, S. M. Asif-Ul-Alam, and K. Monalisa, “Chemical composition, antioxidant capacities and storage stability of Citrus macroptera and Garcinia pedunculata fruits,” Emirates Journal of Food and Agriculture, vol. 27, no. 3, pp. 275–282, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Kagyung, P. R. Gajurel, P. Rethy, and B. Singh, “Ethnomedicinal plants used for gastro-intestinal diseases by Adi tribes of Dehang-Debang Biosphere Reserve in Arunachal Pradesh,” Indian Journal of Traditional Knowledge, vol. 9, no. 3, pp. 496–501, 2010. View at Google Scholar · View at Scopus
  11. T. Mudoi, D. C. Deka, and R. Devi, “In vitro antioxidant activity of Garcinia pedunculata, an indigenous fruit of North Eastern (NE) region of India,” International Journal of PharmTech Research, vol. 4, no. 1, pp. 334–342, 2012. View at Google Scholar · View at Scopus
  12. P. S. Negi, G. K. Jayaprakasha, and B. S. Jena, “Antibacterial activity of the extracts from the fruit rinds of Garcinia cowa and Garcinia pedunculata against food borne pathogens and spoilage bacteria,” LWT - Food Science and Technology, vol. 41, no. 10, pp. 1857–1861, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. F. J. Ravi Mundugar, R. Shrinidhi, L. Das, and R. Sudhakara, “Anti inflammatory activity of aqueous extract of fruits of garcinia pedunculata in experimental animals,” American Journal of Pharm Tech Research, vol. 4, no. 3, 2014. View at Google Scholar
  14. R. Sarma, S. Kumari, R. Elancheran, M. Deori, and R. Devi, “Polyphenol rich extract of Garcinia pedunculata fruit attenuates the hyperlipidemia induced by high fat diet,” Frontiers in Pharmacology, vol. 7, article no. 294, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Mundugaru, M. C. Varadharajan, and R. Basavaiah, “Hepatoprotective activity of fruit extract of garcinia pedunculata,” Bangladesh Journal of Pharmacology, vol. 9, no. 4, pp. 483–487, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Mundugaru, P. Udaykumar, S. Senthilkumar, and S. Bhat, “Cardioprotective activity of fruit of garcinia pedunculata on isoprenaline-induced myocardial infarction in rat,” Bangladesh Journal of Pharmacology, vol. 11, no. 1, pp. 231–235, 2016. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Sahu, B. Das, and A. Chatterjee, “Polyisoprenylated benzophenones from Garcinia pedunculata,” Phytochemistry, vol. 28, no. 4, pp. 1233–1235, 1989. View at Publisher · View at Google Scholar · View at Scopus
  18. G. K. Jayaprakasha, B. S. Jena, and K. K. Sakariah, “Improved liquid chromatographic method for determination of organic acids in leaves, pulp, fruits, and rinds of Garcinia,” Journal of AOAC International, vol. 86, no. 5, pp. 1063–1068, 2003. View at Google Scholar · View at Scopus
  19. R. Sarma, M. Das, T. Mudoi, K. K. Sharma, J. Kotoky, and R. Devi, “Evaluation of antioxidant and antifungal activities of polyphenol-rich extracts of dried pulp of garcinia pedunculata roxb. And garcinia morella gaertn. (clusiaceae),” Tropical Journal of Pharmaceutical Research, vol. 15, no. 1, pp. 133–140, 2016. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Paul, M. Y. Ali, N.-E. Rumpa et al., “Assessment of toxicity and beneficiary effects of garcinia pedunculata on the hematological, biochemical, and histological homeostasis in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 4686104, 11 pages, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Lanjhiyana et al., “Antidiabetic activity of methanolic extract of stem bark of Elaeodendron glaucum Pers. in alloxanized rat model,” Advances in Applied Science Research, vol. 2, no. 1, pp. 47–62, 2011. View at Google Scholar
  22. O. Yildiz, Z. Can, A. Q. Laghari, H. Şahin, and M. Malkoç, “Wild edible mushrooms as a natural source of phenolics and antioxidants,” Journal of Food Biochemistry, vol. 39, no. 2, pp. 148–154, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Afroz, E. Tanvir, S. Paul, N. C. Bhoumik, S. H. Gan, and M. I. Khalil, “DNA damage inhibition properties of sundarban honey and its phenolic composition,” Journal of Food Biochemistry, vol. 40, pp. 436–445, 2016. View at Google Scholar
  24. D. Ahmed, V. Kumar, A. Verma et al., “Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats,” BMC Complementary and Alternative Medicine, vol. 14, article no. 243, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Ringler and L. Dabich, “Hematology and clinical biochemistry,” The Laboratory Rat, vol. 1, pp. 105–121, 1979. View at Google Scholar
  26. Z. Liu, C. Li, M. Li, D. Li, and K. Liu, “The subchronic toxicity of hydroxysafflor yellow A of 90 days repeatedly intraperitoneal injections in rats,” Toxicology, vol. 203, no. 1–3, pp. 139–143, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  28. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Publisher · View at Google Scholar · View at Scopus
  29. H. M. Carleton, Histological Technique, vol. 195, Oxford University Press, London, UK, 1980.
  30. P. Subash Babu, S. Prabuseenivasan, and S. Ignacimuthu, “Cinnamaldehyde-A potential antidiabetic agent,” Phytomedicine, vol. 14, no. 1, pp. 15–22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Kanter, O. Coskun, A. Korkmaz, and S. Oter, “Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats,” Anatomical Record—Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, vol. 279, no. 1, pp. 685–691, 2004. View at Google Scholar · View at Scopus
  32. K. M. West, M. M. S. Ahuja, P. H. Bennett et al., “The role of circulating glucose and triglyceride concentrations and their interactions with other 'risk factors' as determinants of arterial disease in nine diabetic population samples from the WHO multinational study,” Diabetes Care, vol. 6, no. 4, pp. 361–369, 1983. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Droumaguet, B. Balkau, D. Simon et al., “Use of HbA1c in predicting progression to diabetes in French men and women,” Diabetes Care, vol. 29, no. 7, pp. 1619–1625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. D. E. Goldstein, R. R. Little, H.-M. Wiedmeyer, J. D. England, C. L. Rohlfing, and A. L. Wilke, “Is glycohemoglobin testing useful in diabetes mellitus? Lessons from the diabetes control and complications trial,” Clinical Chemistry, vol. 40, no. 8, pp. 1637–1640, 1994. View at Google Scholar · View at Scopus
  35. H. F. Burr, “Evaluation of glycosylated hemoglobin in diabetic patients,” Diabetes, vol. 30, no. 7, pp. 613–617, 1981. View at Publisher · View at Google Scholar · View at Scopus
  36. R. J. Koenig, C. M. Peterson, R. L. Jones, C. Saudek, M. Lehrman, and A. Cerami, “Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus,” The New England Journal of Medicine, vol. 295, no. 8, pp. 417–420, 1976. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Samarghandian, M. Azimi-Nezhad, and T. Farkhondeh, “Catechin treatment ameliorates diabetes and its complications in streptozotocin-induced diabetic rats,” Dose-Response, vol. 15, no. 1, 2017. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Madhuri and P. R. Naik, “Modulatory effect of garcinol in streptozotocin-induced diabetic Wistar rats,” Archives of Physiology and Biochemistry, pp. 1–8, 2017. View at Publisher · View at Google Scholar
  39. E. R. B. Shanmugasundaram, K. L. Gopinath, K. R. Shanmugasundaram, and V. M. Rajendran, “Possible regeneration of the islets of langerhans in streptozotocin-diabetic rats given Gymnema sylvestre leaf extracts,” Journal of Ethnopharmacology, vol. 30, no. 3, pp. 265–279, 1990. View at Publisher · View at Google Scholar · View at Scopus
  40. U. C. S. Yadav, K. Moorthy, and N. Z. Baquer, “Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats,” Molecular and Cellular Biochemistry, vol. 268, no. 1-2, pp. 111–120, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. E. R. Briones, S. J. T. Mao, P. J. Palumbo, W. M. O'Fallon, W. Chenoweth, and B. A. Kottke, “Analysis of plasma lipids and apolipoproteins in insulin-dependent and noninsulin-dependent diabetics,” Metabolism, vol. 33, no. 1, pp. 42–49, 1984. View at Publisher · View at Google Scholar · View at Scopus
  42. E. Nikkila, “Plasma lipid and lipoprotein abnormalities in diabetes,” in Diabetes and Heart Disease, pp. 133–167, Elsevier, Amsterdam, Netherlands, 1984. View at Google Scholar
  43. P. N. Pushparaj, H. K. Low, J. Manikandan, B. K. H. Tan, and C. H. Tan, “Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats,” Journal of Ethnopharmacology, vol. 111, no. 2, pp. 430–434, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. B. G. Brown, X.-Q. Zhao, D. E. Sacco, and J. J. Albers, “Lipid lowering and plaque regression: New insights into prevention of plaque disruption and clinical events in coronary disease,” Circulation, vol. 87, no. 6, pp. 1781–1791, 1993. View at Publisher · View at Google Scholar · View at Scopus
  45. F. P. Schena and L. Gesualdo, “Pathogenetic mechanisms of diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 16, no. 3, supplement 1, pp. S30–S33, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Ghosh and S. A. Suryawanshi, “Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats,” Indian Journal of Experimental Biology (IJEB), vol. 39, no. 8, pp. 748–759, 2001. View at Google Scholar · View at Scopus
  47. A. Larcan et al., “Light and electron microscopic study of hepatic lesions in the course of hyperlactatemia in diabetic patients,” Diabete and Metabolisme, vol. 5, no. 2, pp. 103–112, 1979. View at Google Scholar
  48. M. H. Abdel-Wahab and A. R. A. Abd-Allah, “Possible protective effect of melatonin and/or desferrioxamine against streptozotocin-induced hyperglycaemia in mice,” Pharmacological Research, vol. 41, no. 5, pp. 533–537, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. T. Hünkar, F. Aktan, A. Ceylan, and Ç. Karasu, “Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin-diabetic rats,” Cell Biochemistry & Function, vol. 20, no. 4, pp. 297–302, 2002. View at Publisher · View at Google Scholar · View at Scopus
  50. R. H. Moghadam and A. Latiffah, “Investigation of lipid profiles and lipid peroxidation in patients with type 2 diabetes,” European Journal of Scientific Research, vol. 28, no. 1, pp. 6–13, 2009. View at Google Scholar · View at Scopus
  51. J. M. Matés, C. Pérez-Gómez, and I. N. de Castro, “Antioxidant enzymes and human diseases,” Clinical Biochemistry, vol. 32, no. 8, pp. 595–603, 1999. View at Publisher · View at Google Scholar