Evidence-Based Complementary and Alternative Medicine

Research Article

Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway

Table 6

Signaling pathway prediction of DEGs between BQG and BLM group from KEGG database.


ID	Description	P-value	Significant symbol genes

UP-REGULATED

ko03010	Ribosome	0.001525	Rpl30, Rpl26, Rpl35a, Rpl31, Rps27a, Rpl27-ps3
ko04924	Renin secretion	0.002328	Calm4, Gucy1a3, Adcyap1r1, Gucy1b3
ko03030	DNA replication	0.004173	Rnaseh2b, Rpa3, Mcm6
ko04624	Toll and Imd signaling pathway	0.004522	Birc3, Tab2, Faf1
ko04713	Circadian entrainment	0.008117	Calm4, Gucy1a3, Adcyap1r1, Gucy1b3
ko05031	Amphetamine addiction	0.018481	Calm4, Fosb, Ppp1cb
ko00230	Purine metabolism	0.018499	Nt5e, Entpd5, Gucy1a3, Gucy1b3, Pde4d
ko04970	Salivary secretion	0.020157	Calm4, Gucy1a3, Gucy1b3
ko04611	Platelet activation	0.022505	Gucy1a3, Vamp8, Ppp1cb, Gucy1b3
ko04270	Vascular smooth muscle contraction	0.023148	Calm4, Gucy1a3, Ppp1cb, Gucy1b3

DOWN-REGULATED

ko04550	Signaling pathways regulating pluripotency of stem cells	0.001454	Inhbb, Wnt4, Map2k2, Dvl1, Mapk13, Id1, Fgfr3, Axin2, Tcf3, Myf5, Wnt9a, Fzd8, Fzd2, Dlx5, Wnt3a, Fgfr4
ko04360	Axon guidance	0.002752	Wnt4, Sema3f, Sema4g, Efnb1, Plxna3, Ssh3, Epha2, Pak6, Abl1, Pak4, Ephb3, Plxnb1, Efna2, Fes, Nck2, Ephb6, Sema4f, Sema4b
ko04115	p53 signaling pathway	0.002898	Sfn, Gtse1, Gadd45g, Gadd45a, Rprm, Gadd45b, Pidd1, Sesn2, Bbc3, Bax
ko04390	Hippo signaling pathway	0.003971	Wnt4, Dvl1, Llgl2, Id1, Axin2, Llgl1, Wnt9a, Fzd8, Fzd2, Wwc1, Scrib, Tead3, Ajuba, Wnt3a, Bbc3, Smad7
ko04330	Notch signaling pathway	0.006239	Dvl1, Hes1, Dtx2, Lfng, Jag2, Notch1, Ncor2
ko05166	HTLV-I infection	0.006668	Wnt4, Dvl1, Cdc20, Ranbp3, Ranbp1, Crtc1, Map3k14, Tcf3, Pold1, H2-Q2, Wnt9a, Msx1, Bcl2l1, Fzd8, Fzd2, Cdkn2b, H2-Q6, Ltbr, Wnt3a, Pdgfa, Slc2a1, Mybl2, Bax, Fosl1
ko04014	Ras signaling pathway	0.010254	Ngfr, Map2k2, Pla2g6, Rgl2, Arf6, Gnb2, Fgfr3, Rin1, Epha2, Pak6, Abl1, Pak4, Rasal3, Pla2g4f, Efna2, Bcl2l1, Zap70, Pdgfa, Fgfr4, Rasal1
ko05322	Systemic lupus erythematosus	0.012114	Hist1h2bl, Hist3h2a, Hist1h2br, Hist1h4n, Hist1h4m, H2afz, Hist1h3d, H2afj, Hist1h4k, Hist2h3c2, Hist1h3i, Hist1h2bg, Hist1h2bk, H2afx
ko00680	Methane metabolism	0.012152	Shmt2, Eno1b, Pfkl, Phgdh, Eno1
ko05230	Central carbon metabolism in cancer	0.014355	Slc16a3, Map2k2, Fgfr3, Hk3, Pfkl, Sirt6, Erbb2, Slc2a1