Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway

Table 7

The significantly enriched GO terms of DEGs ranking top 20.

Ontology	ID	Term	Gene count	P-value
UP-REGULATED
biological process	GO: 0008152	metabolic process	119	4.60E-07
	GO: 0044237	cellular metabolic process	107	4.20E-06
	GO: 0044238	primary metabolic process	108	6.30E-06
	GO: 0071704	organic substance metabolic process	111	6.90E-06
molecular function	GO: 0003735	structural constituent of ribosome	11	5.00E-07
	GO: 0035662	Toll-like receptor 4 binding	3	5.10E-06
cellular component	GO: 0044445	cytosolic part	12	1.20E-06
	GO: 0022626	cytosolic ribosome	9	1.60E-06
	GO: 0022625	cytosolic large ribosomal subunit	7	4.10E-06
	GO: 0044391	ribosomal subunit	10	9.50E-06
	GO: 0005840	ribosome	11	1.30E-05
	GO: 0005683	U7 snRNP	3	2.90E-05
	GO: 0005687	U4 snRNP	3	8.40E-05
	GO: 0005615	extracellular space	29	0.00012
	GO: 0015934	large ribosomal subunit	7	0.00014
	GO: 0005576	extracellular region	58	0.00016
	GO: 0032991	macromolecular complex	61	0.00016
	GO: 0034709	methylosome	3	0.00018
	GO: 0044421	extracellular region part	52	0.00023
	GO: 0034719	SMN-Sm protein complex	3	0.00033
DOWN-REGULATED
cellular component	GO: 0044424	intracellular part	839	3.60E-30
	GO: 0005622	intracellular	858	1.50E-27
	GO: 0043229	intracellular organelle	737	6.00E-22
	GO: 0043226	organelle	787	1.90E-21
	GO: 0005737	cytoplasm	660	1.30E-19
	GO: 0043227	membrane-bounded organelle	724	7.80E-18
	GO: 0044446	intracellular organelle part	511	1.30E-15
	GO: 0043231	intracellular membrane-bounded organelle	630	2.10E-15
	GO: 0044422	organelle part	519	5.80E-15
molecular function	GO: 0005515	protein binding	567	9.00E-22
biological process	GO: 0044763	single-organism cellular process	641	2.60E-18
	GO: 0007275	multicellular organism development	364	2.70E-17
	GO: 0048731	system development	333	5.90E-17
	GO: 0009888	tissue development	166	2.00E-16
	GO: 0048518	positive regulation of biological process	379	2.50E-15
	GO: 0048513	animal organ development	260	3.70E-15
	GO: 0048856	anatomical structure development	383	3.90E-15
	GO: 0043588	skin development	48	4.90E-15
	GO: 0044707	single-multicellular organism process	407	5.00E-15
	GO: 0032502	developmental process	407	1.10E-14