Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis

Figure 2

Acupuncture at bilateral ST35 acupoints improved KOA relative behaviors and articular pathology score. (a) Schematic diagram for the time frame of the experiment. (b) Representative H&E staining images for articular pathology assessment in the MIA- and EA-treated groups. The scale bar is 200 μm. (e) OARSI scores are presented as the mean ± SD; Kruskal-Wallis test was used and P < 0.001 versus Control group; ^#P < 0.05 versus MIA+sham EA group; n = 10 per group. ((c) and (d)) Paw withdrawal thresholds of the ipsilateral hind paws and weight-bearing deficits were assessed in MIA- and EA-treated rats. Two-way repeated measures ANOVA followed by Bonferroni’s post hoc test was used, P < 0.001 versus Control group; ^#P < 0.05 and ^##P < 0.01 versus MIA+sham EA group; n = 8 per group. Data are presented as the mean ± SEM.

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