Research Article

Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis

Figure 4

Intrathecal glycine administration attenuated acupoint sensitization in KOA rats. (a) Schematic diagram for the time frame of the experiment. (b) The concentration of glycine in bilateral spinal dorsal horn detected by microdialysis in KOA or control rats. One-way ANOVA followed by Tukey’s post hoc test was used. P < 0.05 versus Control-L group; #P < 0.05 versus Control-R group; n = 6 per group. (c-e) Paw withdrawal mechanical threshold in bilateral acupoints or nonacupoint areas of KOA and control rats. Two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test was used. P < 0.05 and P < 0.01 versus MIA+NS-L group; #P < 0.05 and ##P < 0.01 versus MIA+NS-R group; n = 8 per group. ((f) and (g)) The total number of mast cells and the percentages of degranulated mast cells in all groups; n = 6 per group. One-way ANOVA followed by Tukey’s post hoc test was used. P < 0.05 and P < 0.01 versus MIA+NS-L group; #P < 0.05 and ##P < 0.01 versus MIA+NS-R group; n = 6 per group. All data are presented as the mean ± SEM.
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