Research Article

Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis

Figure 6

Selective inhibition of GlyT2 attenuated ST35 acupoint sensitization in KOA rats. (a) Schematic diagram for the time frame of the experiment. (b-d) Paw withdrawal mechanical threshold was assessed by stimulating at bilateral ST35, GB37, or nonacupoint. P < 0.05 and P < 0.01 versus MIA+NS-L group; #P < 0.05 versus MIA+NS-R group; n = 8 per group. Two-way repeated-measures ANOVA followed by Bonferroni’s post hoc test was used. (e) The concentration of glycine in bilateral spinal dorsal horn detected by microdialysis in unilateral KOA or ORG injected rats. One-way ANOVA followed by Tukey’s post hoc test was used. P < 0.05 versus MIA+ORG-L group; #P < 0.05 versus MIA+ORG-R group; n = 6 per group. ((f) and (g)) The total number of mast cells and the percentages of degranulated mast cells in all groups; One-way ANOVA followed by Tukey’s post hoc test was used. P < 0.05 versus MIA+NS-L group; #P < 0.05 versus MIA+NS-R group; n = 6 per group. All data are presented as the mean ± SEM. ORG: ORG25543.
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