No Inhibitory concentrations (cell lines) References Isolated compound 12 ICμ g/mL (MCF-7), ICμ g/mL (LU), ICμ g/mL (Hep-G2) and ICμ g/mL (KB) [37 ] 18-22 Inactive (KB and Vero) [7 ] 33 ICμ g/mL (KB), ICμ g/mL (MCF-7), ICμ g/mL (NCI-H187) and ICμ g/mL (Vero) [32 ] 34 ICμ g/mL (KB), ICμ g/mL (MCF-7), ICμ g/mL (NCI-H187) and ICμ g/mL (Vero) [32 ] 35 ICμ g/mL (KB), ICμ g/mL (MCF-7), ICμ g/mL (NCI-H187) and ICμ g/mL (Vero) [32 ] 36 ICμ g/mL (KB), ICμ g/mL (MCF-7), ICμ g/mL (NCI-H187) and ICμ g/mL (Vero) [32 ] 37 ICμ g/mL (KB), ICμ g/mL (MCF-7), ICμ g/mL (NCI-H187) and ICμ g/mL (Vero) [32 ] 38 ICμ g/mL (KB, MCF-7, NCI-H187, Vero) [32 ] 39 ICμ g/mL (KB, MCF-7, NCI-H187, Vero) [32 ] 40 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ g/mL (HUVEC), ICμ g/mL (HL60), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 41 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ g/mL (HUVEC), ICμ g/mL (HL60), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 42 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ g/mL (HUVEC), ICμ g/mL (HL60), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 43 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7) and ICμ g/mL (HL60) [14 ] 44 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7) and ICμ g/mL (HL60) [14 ] 45 ICμ g/mL (KB, Lu1, Col2, LNCaP and MCF-7) and ICμ g/mL (HL60) [14 ] 46 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP) and ICμ g/mL (MCF-7) [14 ] 47 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP) and ICμ g/mL (MCF-7) [14 ] 48 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7) and ICμ g/mL (HUVEC) [14 ] 49 ICμ g/mL (KB, Lu1, LNCaP), ICμ g/mL (Col2), ICμ g/mL (MCF-7), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 50/51 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7) and ICμ g/mL (HL60) [14 ] 52/53 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP) and ICμ g/mL (MCF-7) [14 ] 54/55 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 56 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP) and ICμ g/mL (MCF-7) [14 ] 57 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 , 14 ] 58 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7) and ICμ g/mL (HL60) [14 ] 59 ICμ g/mL (KB), ICμ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP) and ICμ g/mL (MCF-7) [14 ] 60 ICμ g/mL (KB, Lu1, Col2, LNCaP and MCF-7) and ICμ g/mL (HL60) [14 ] 61 ICμ g/mL (HCT116, A375, A549) [13 ] 62/63 ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 ] 64/65 ICμ M (HCT116, A375 and A549) [13 ] 66/67 ICμ M (HCT116, A375 and A549) [13 ] 68 ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 ] 69 ICμ M (HCT116, A375 and A549) [13 ] 70 ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 ] 71 ICμ M (HCT116), ICμ M (A375) and ICμ M (A549) [13 ] 72 ICμ M (KB)μ M (Vero), ICμ M (HCT116), ICμ M (A375), ICμ M (A549), ICμ g/mL (KB)μ g/mL (Lu1), ICμ g/mL (Col2), ICμ g/mL (LNCaP), ICμ g/mL (MCF-7), ICμ g/mL (HUVEC) and ICμ g/mL (HL60) [7 ]13 ], [14 ] 75 EDμ g/mL (P-388), EDμ g/mL (Col2), EDμ g/mL (MCF-7)μ g/mL (ASK), EDμ g/mL (Hek293) and Inactive (KB, Lu-1 and T24) [36 ] 76 ICμ g/mL (KB), ICμ g/mL (Hep-G2) and ICμ g/mL (RD) [35 ] 77 ICμ g/mL (KB), ICμ g/mL (Hep-G2) and ICμ g/mL (RD) [35 ] 79 and 107 ICμ g/mL (MCF-7, LU, Hep-G2 and KB) [37 ] 83 and 87 Inactive (KB and Vero) [7 ] 94 > 5.0 μ g/mL (KB and RD) and 1.5 μ g/mL (Hep-G2) [35 ] 95 ICμ g/mL (KB), ICμ g/mL (Hep-G2) and ICμ g/mL (RD) [35 ] 116 Inactive (KB, MCF-7 and NCI-H187) [9 ] 119 Inactive (KB and Vero) [7 ] 123 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H178) [10 ] 124 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 125 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 130 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 131 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 134 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H178) [10 ] 139 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 140 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H178) [10 ] 141 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H178) [10 ] 143 ICμ g/mL (KB), ICμ g/mL (MCF-7) and ICμ g/mL (NCI-H178) [9 ] 145 LDμ g/mL [5 ] 146 LDμ g/mL [5 ] 147 ICμ M (KB), Inactive (MCF7) and ICμ M (NCI-H187) [40 ] 148 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H187) [40 ] 149 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H187) [40 ] 150 ICμ M (KB), ICμ M (MCF7) and ICμ M (NCI-H187) [40 ] 151 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H187) [40 ] 152 ICμ M (KB), ICμ M (MCF7) and ICμ M (NCI-H187) [40 ] 153 ICμ M (KB), Inactive (MCF-7) and ICμ M (NCI-H187) [40 ] 154 ICμ M (KB), ICμ M (MCF7) and ICμ M (NCI-H187) [40 ] 155 ICμ M (KB), ICμ M (MCF-7) and ICμ M (NCI-H187) [40 ] 158 LDμ g/mL [5 ] 161 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 162 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 163 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 164 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 166 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 167 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 168 ICμ M (KB), ICμ M (MCF-7), ICμ M (NCI-H187) and ICμ M (Vero) [38 ] 174-176 Inactive (KB, MCF-7, NCI-H187 and Vero) [38 ] 201-203 Inactive (KB and Vero) [7 ] Plant extracts n -Hexane extract of M. sinensis ICμ g/mL (MCF-7), ICμ g/mL (LU), ICμ g/mL (Hep-G2) and ICμ g/mL (KB) [37 ] Ethyl acetate extract of M. sinensis ICμ g/mL (MCF-7), ICμ g/mL (LU), ICμ g/mL (Hep-G2)μ g/mL (KB) [37 ] n -Butanol extract of M. sinensis ICμ g/mL (MCF-7 and KB) [37 ] n -Hexane extract of M. smithiae EDμ g/mL (P-388), EDμ g/mL (KB), EDμ g/mL (Col2), EDμ g/mL (MCF-7), EDμ g/mL (Lu1), EDμ g/mL (T24), EDμ g/mL (ASK) and EDμ g/mL (Hek293) [36 ] Ethyl acetate extract of M. smithiae EDμ g/mL (P-388), EDμ g/mL (KB), EDμ g/mL (Col2), EDμ g/mL (MCF-7), EDμ g/mL (Lu1), EDμ g/mL (T24), EDμ g/mL (ASK) and EDμ g/mL (Hek293) [36 ] Methanol and acetone extracts of M. smithiae Inactive (P-388, KB, Col2, MCF-7, Lu1, T24, ASK and Hek293) [36 ]
