2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-<i>κ</i>B Signalling Pathways in Lung Cancer A549 Cells

<div>Effects of HHDMNQ on the morphological changes, apoptosis rate, and intrinsic apoptosis pathway in A549 cells. (a) A549 cells treated with 6 <i>μ</i>M 5-FU or HHDMNQ for 3, 6, 12, and 24 h fluorescence microscopic images (magnification, 200×) and relative fluorescence intensity. (b) Apoptosis distribution of A549 cells was determined by Annexin V-FITC/PI staining and quantification of early and late apoptotic cells. (c) A549 cells treated with 6 <i>μ</i>M HHDMNQ for 3, 6, 12, and 24 h. 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Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-<i>κ</i>B Signalling Pathways in Lung Cancer A549 Cells 

Figure 4 | 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells 