2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-<i>κ</i>B Signalling Pathways in Lung Cancer A549 Cells

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Cell name</td><td class="align_center">Shikonin (<i>μ</i>M)</td><td class="align_center">5-FU (<i>μ</i>M)</td><td class="align_center">HEDMNQ (<i>μ</i>M)</td><td class="align_center">HHDMNQ (<i>μ</i>M)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">A549</td><td class="align_center">52.83 ± 2.02</td><td class="align_center">52.83 ± 2.02</td><td class="align_center">10.91 ± 1.22</td><td class="align_center">5.62 ± 2.16</td></tr><tr><td class="align_left">NCI-H23</td><td class="align_center">71.55 ± 2.35</td><td class="align_center">69.31 ± 3.39</td><td class="align_center">14.78 ± 2.31</td><td class="align_center">6.62 ± 1.65</td></tr><tr><td class="align_left">NCI-H460</td><td class="align_center">79.19 ± 2.12</td><td class="align_center">74.14 ± 1.84</td><td class="align_center">14.22 ± 2.06</td><td class="align_center">9.07 ± 1.38</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>IC<sub>50</sub> values of shikonin, 5-FU, HEDMNQ, and HHDMNQ in lung cancer cells.</div>

Evidence-Based Complementary and Alternative Medicine

tab1

Table 1

Table 1: 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-<i>κ</i>B Signalling Pathways in Lung Cancer A549 Cells 

Table 1 | 2-(6-Hydroxyhexylthio)-5,8-dimethoxy-1,4-naphthoquinone Induces Apoptosis through ROS-Mediated MAPK, STAT3, and NF-κB Signalling Pathways in Lung Cancer A549 Cells 