Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling

Table 1

The SGC7901/DDP cell line exhibited multidrug resistance to DDP, DOX, and 5-fluorouracil (5-FU).

Cell line	IC50 of DDP (μM)	IC50 of DOX (μM)	IC50 of 5-FU (μM)
SGC7901	0.714	1.074	6.139
SGC7901/DDP	1.319	1.612	292.8
Resistance index	1.86	1.501	47.70

Resistance index (RI) = IC50 (SGC7901/DDP)/IC50 (SGC7901). The RIs of DDP, DOX, and 5-fluorouracil (5-FU) were 1.86, 1.50, and 47.70, respectively (Table 1). Resistance index of BBD on SGC7901/DDP cells.