Multiple Roles of SIRT2 in Regulating Physiological and Pathological Signal Transduction

Figure 1

SIRT2 is involved in lipid metabolism. SIRT2 affects lipid synthesis through ACLY. P300/PCAF can stabilize ACLY by acetylation, thereby promoting lipid synthesis. SIRT2 degrades ACLY by deacetylation to inhibit lipid synthesis. SIRT2 promotes the binding of SREBP-2 to the SRE by promoting the nuclear translocation of SREBP-2, thereby promoting the transcription of cholesterol synthesis-related genes and ultimately promoting the synthesis of cholesterol. SIRT2 inhibits lipid synthesis by deacetylating HNF4α. SIRT2 promotes fatty acid oxidation and inhibits lipid synthesis by inhibiting the nuclear translocation of FOXO1. In addition, SIRT2 promotes fatty acid oxidation through the deacetylation of PGC-1.